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Table 1 Results of Spearman correlation analysis of continuous copy number values of the imprinted genes with log(IC50) satisfying pSegmFDR < 0.05 and Spearman |ρ|> 0.3

From: Increased copy number of imprinted genes in the chromosomal region 20q11-q13.32 is associated with resistance to antitumor agents in cancer cell lines

Gene

Agent

Sample size

Spearman ρ

p0

Gene category

Location

pSegmFDR

MIR298

Ispinesib mesylate

567

0.3393

9.54 × 10–17

ncRNA

20q13.32

3.74 × 10–8

GNAS-AS1

Ispinesib mesylate

567

0.3393

9.54 × 10–17

ncRNA

20q13.32

3.74 × 10–8

MIR296

Ispinesib mesylate

567

0.3393

9.54 × 10–17

ncRNA

20q13.32

3.74 × 10–8

GNAS

Ispinesib mesylate

567

0.3390

1.03 × 10–16

Protein-coding

20q13.32

3.74 × 10–8

MIR298

T0901317

565

0.3333

4.03 × 10–16

ncRNA

20q13.32

9.08 × 10–7

GNAS-AS1

T0901317

565

0.3333

4.03 × 10–16

ncRNA

20q13.32

9.08 × 10–7

MIR296

T0901317

565

0.3333

4.03 × 10–16

ncRNA

20q13.32

9.08 × 10–7

GNAS

T0901317

565

0.3315

5.83 × 10–16

Protein-coding

20q13.32

9.08 × 10–7

PSIMCT-1

Axitinib

506

0.3295

2.83 × 10–14

Pseudogene

20q11.21

2.48 × 10–6

HM13

Axitinib

506

0.3295

2.83 × 10–14

Protein-coding

20q11.21

2.48 × 10–6

HM13

T0901317

565

0.3239

2.86 × 10–15

Protein-coding

20q11.21

9.08 × 10–7

PSIMCT-1

T0901317

565

0.3239

2.90 × 10–15

Pseudogene

20q11.21

9.08 × 10–7

MIR298

XMD14-99

569

0.3172

9.10 × 10–15

ncRNA

20q13.32

3.18 × 10–6

GNAS-AS1

XMD14-99

569

0.3172

9.10 × 10–15

ncRNA

20q13.32

3.18 × 10–6

MIR296

XMD14-99

569

0.3172

9.10 × 10–15

ncRNA

20q13.32

3.18 × 10–6

HM13

Imatinib

227

0.3150

1.27 × 10–6

Protein-coding

20q11.21

0.01754

PSIMCT-1

Imatinib

227

0.3150

1.27 × 10–6

Pseudogene

20q11.21

0.01754

GNAS

XMD14-99

569

0.3150

1.43 × 10–14

Protein-coding

20q13.32

3.18 × 10–6

MIR298

Cyclopamine

217

0.3149

2.22 × 10–6

ncRNA

20q13.32

0.01338

GNAS-AS1

Cyclopamine

217

0.3149

2.22 × 10–6

ncRNA

20q13.32

0.01338

MIR296

Cyclopamine

217

0.3149

2.22 × 10–6

ncRNA

20q13.32

0.01338

MIR298

BX-912

569

0.3129

2.17 × 10–14

ncRNA

20q13.32

3.87 × 10–6

GNAS-AS1

BX-912

569

0.3129

2.17 × 10–14

ncRNA

20q13.32

3.87 × 10–6

MIR296

BX-912

569

0.3129

2.17 × 10–14

ncRNA

20q13.32

3.87 × 10–6

GNAS

XMD13-2

569

0.3120

2.62 × 10–14

Protein-coding

20q13.32

2.48 × 10–6

GNAS

BX-912

569

0.3114

2.90 × 10–14

Protein-coding

20q13.32

3.87 × 10–6

GNAS

Cyclopamine

217

0.3109

3.01 × 10–6

Protein-coding

20q13.32

0.01338

HM13

S-Trityl-L-cysteine

221

0.3108

2.46 × 10–6

Protein-coding

20q11.21

0.00495

PSIMCT-1

S-Trityl-L-cysteine

221

0.3108

2.46 × 10–6

Pseudogene

20q11.21

0.00495

GNAS

QL-XI-92

569

0.3106

3.41 × 10–14

Protein-coding

20q13.32

1.57 × 10–6

MIR298

XMD13-2

569

0.3093

4.41 × 10–14

ncRNA

20q13.32

2.48 × 10–6

GNAS-AS1

XMD13-2

569

0.3093

4.41 × 10–14

ncRNA

20q13.32

2.48 × 10–6

MIR296

XMD13-2

569

0.3093

4.41 × 10–14

ncRNA

20q13.32

2.48 × 10–6

MIR298

QL-XI-92

569

0.3092

4.53 × 10–14

ncRNA

20q13.32

1.57 × 10–6

GNAS-AS1

QL-XI-92

569

0.3092

4.53 × 10–14

ncRNA

20q13.32

1.57 × 10–6

MIR296

QL-XI-92

569

0.3092

4.53 × 10–14

ncRNA

20q13.3

1.57 × 10–6

MIR298

GSK1070916

555

0.3072

1.37 × 10–13

ncRNA

20q13.32

2.76 × 10–6

GNAS-AS1

GSK1070916

555

0.3072

1.37 × 10–13

ncRNA

20q13.32

2.76 × 10–6

MIR296

GSK1070916

555

0.3072

1.37 × 10–13

ncRNA

20q13.32

2.76 × 10–6

GNAS

GSK1070916

555

0.3057

1.81 × 10–13

Protein-coding

20q13.32

2.76 × 10–6

MIR298

UNC1215

553

0.3054

2.13 × 10–13

ncRNA

20q13.32

5.28 × 10–6

GNAS-AS1

UNC1215

553

0.3054

2.13 × 10–13

ncRNA

20q13.32

5.28 × 10–6

MIR296

UNC1215

553

0.3054

2.13 × 10–13

ncRNA

20q13.32

5.28 × 10–6

MIR298

GSK429286A

569

0.3052

9.81 × 10–14

ncRNA

20q13.32

1.50 × 10–6

GNAS-AS1

GSK429286A

569

0.3052

9.81 × 10–14

ncRNA

20q13.32

1.50 × 10–6

MIR296

GSK429286A

569

0.3052

9.81 × 10–14

ncRNA

20q13.32

1.50 × 10–6

BLCAP

Ispinesib mesylate

567

0.3044

1.28 × 10–13

Protein-coding

20q11.23

3.74 × 10–8

NNAT

Ispinesib mesylate

567

0.3044

1.28 × 10–13

Protein-coding

20q11.23

3.74 × 10–8

GNAS

UNC1215

553

0.3037

2.91 × 10–13

Protein-coding

20q13.32

5.28 × 10–6

HM13

TL-2–105

569

0.3034

1.40 × 10–13

Protein-coding

20q11.21

1.34 × 10–7

GNAS

GSK429286A

569

0.3028

1.59 × 10–13

Protein-coding

20q13.32

1.50 × 10–6

GNAS

Masitinib

568

0.3023

1.81 × 10–13

Protein-coding

20q13.32

2.31 × 10–6

PSIMCT-1

TL-2–105

569

0.3021

1.79 × 10–13

Pseudogene

20q11.21

1.34 × 10–7

PSIMCT-1

UNC1215

553

0.3019

4.05 × 10–13

Pseudogene

20q11.21

5.28 × 10–6

HM13

Ispinesib mesylate

567

0.3004

2.74 × 10–13

Protein-coding

20q11.21

3.74 × 10–8

  1. Sample size number of cell lines with available data used in correlation analysis; Spearman ρ Spearman correlation coefficient; p0 p value prior to FDR adjustment; pSegmFDR p value after FDR adjustment using the maximal p values from each chromosomal segment
  2. Segment assignment of all imprinted genes is provided in Additional file 3: Table S2. All correlations presented in the table also satisfied FDR-adjusted p < 0.05 if considering all genes independently, without grouping them into segments (pFDR < 0.05). All agents listed in the table were from the GDSC dataset
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Clinical Epigenetics

ISSN: 1868-7083

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