Fig. 5
From: Epigenetically regulated PCDHB15 impairs aggressiveness of metastatic melanoma cells
PCDHB15 overexpression impairs WM266-4 lung metastasis formation in vivo. WM266-4 overexpressing PCDHB15 (clone 8, 12, 13) or mock cells (with void vector) were injected in the tail vein (IV) of SCID mice. Lungs were recovered for immunohistochemical analysis 21 days after injection. A A representative image of the stained lung is shown for each group. Black arrows indicate metastases. Plots representing the median of number (B) and size (C) of metastases on one slice for each mouse are shown. n = 15 for mock, clone 8, clone 12; n = 14 for clone 13. Medians and SEM are shown. Mann–Whitney test; **p value < 0.01, ***p value < 0.001