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Table 1 Clinical and pathological aspects, staging and treatment of penile squamous cell carcinoma participants

From: HPV infection and 5mC/5hmC epigenetic markers in penile squamous cell carcinoma: new insights into prognostics

 

N (%)

Age (years)

 Mean (range)

63.8 years (18–103)

 < 40

17/224 (7.6)

 40–60

74/224 (33.2)

 > 60

133/224 (59.2)

p16INK4a

 No

174/224 (77.7)

 Yes

50/224 (22.3)

hrHPV

 No

88/188 (46.8)

 Yes

100/188 (53.2)

Staging

 pTis + pTa + pT1(a.b)

66/219 (30.1)

 pT2

86/219 (39.3)

 pT3

62/219 (28.3)

 pT4

5/219 (2.3)

Sistemic metastasis

 No

157/188 (83.5)

 Yes

31/188 (16.5)

Lymph node metastasis

 No

124/207 (59.9)

 Yes

83/207 (40.1)

Locoregional recurrence

 No

139/188 (73.9)

 Yes

49/188 (26.1)

PLI

 Mild and Moderate

130/217 (59.9)

 Intense

87/217 (40.1)

PPI

 Mild and Moderate

205/217 (94.5)

 Intense

12/217 (5.5)

ILI

 Mild and Moderate

215/217 (99.1)

 Intense

2/217 (0.9)

IPI

 Mild and Moderate

127/217 (58.5)

 Intense

90/217 (41.5)

Surgical procedure

 Partial amputation

164/224 (73.2)

 Total amputation

33/224 (14.7)

 Others

27/224 (12.1)

Chemotherapy

 No

144/194 (74.2)

 Yes

50/194 (25.8)

Radiotherapy

 No

165/192 (85.9)

 Yes

27/192 (14.1)

  1. pTis carcinoma in situ, pTa noninvasive carcinoma, pT1a subepithelial invasion without lymphovascular invasion, perineural invasion or grade 3, pT1b subepithelial invasion with lymphovascular invasion, perineural invasion or grade 3, pT2 invasion of corpus spongiosum, pT3 invasion of corpus cavernosum, pT4 invasion of adjacent structures including scrotum, prostate and pubic bone, PLI peritumoral lymphocyte infiltrate, PPI peritumoral polymorphonuclear infiltrate, ILI intratumoral lymphocyte infiltrate, IPI intratumoral polymorphonuclear infiltrate