Genome-wide DNA methylation analysis of extreme phenotypes in the identification of novel epigenetic modifications in diabetic retinopathy

Table 3 Top 10 significant genes harboring DMP between stable-NDR group and incidence-DR group

DMS	Gene	CHR	FGD	Cgi	β value			P value
DMS	Gene	CHR	FGD	Cgi	Stable-NDR group	Incident-DR group	Difference	P value
cg05119883	ZMIZ1-AS1	10	Body	Open sea	0.539	0.324	− 0.215	2.61 × 10⁻⁵
cg04145948	BLM	15	Body	Open sea	0.357	0.516	0.159	3.63 × 10⁻⁵
cg19522093	PPP5D1	19	Body	Open sea	0.111	0.215	0.104	5.48 × 10⁻⁵
cg10725855	PCDHB12	5	1stExon	Shore	0.679	0.816	0.137	7.14 × 10⁻⁵
cg17682313	FBXW7	4	5'UTR	Open sea	0.768	0.209	− 0.559	1.09 × 10⁻⁴
cg17457090	NDRG4	16	TSS200	Shore	0.439	0.250	− 0.189	1.66 × 10⁻⁴
cg17666981	TRIM27	6	Body	Open sea	0.639	0.806	0.167	1.82 × 10⁻⁴
cg24093474	NDRG4	16	TSS1500	Shore	0.715	0.515	− 0.200	1.82 × 10⁻⁴
cg17107388	NDRG4	16	TSS1500	Shore	0.710	0.445	− 0.264	1.86 × 10⁻⁴
cg01877814	POLG	15	TSS1500	Shore	0.327	0.218	− 0.109	2.45 × 10⁻⁴

DMP = differentially methylated CpG position; CHR = chromosome; FGD = functional genomic distribution; Cgi = CpG island; NDR = without any diabetic retinopathy; DR = diabetic retinopathy

ISSN: 1868-7083