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Fig. 2 | Clinical Epigenetics

Fig. 2

From: DNA methylation-based detection and prediction of cervical intraepithelial neoplasia grade 3 and invasive cervical cancer with the WID™-qCIN test

Fig. 2

WID™-qCIN test performance in relation to age, diagnosis, and HPV status in the LBC-CIN Diagnostic set. A The WID™-qCIN test discriminates well between controls (up to CIN1) and cases (CIN3/AIS and invasive cervical cancers) in the LBC-CIN Diagnostic Validation Set regardless of age, although performance is higher in individuals over 30 years. B WID™-qCIN values (log scale) in LBC-CIN Diagnostic set samples. The WID™-qCIN threshold of 0.63 (− 0.46 on a log scale, dashed line) was selected a priori based on prior knowledge. C ROC curve analysis of different HPV subtypes (HPV16/18+ vs. other oncHPV+). Curves are not significantly different (DeLong p value = 0.23). D The WID™-qCIN is slightly higher in CIN2 samples from HPV16/HPV18+ individuals compared with other oncHPV subtypes (p = 0.04 in Wilcoxon signed-rank test). AUC area under the curve, PMR percentage methylated reference, oncHPV oncogenic human papillomavirus

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Clinical Epigenetics

ISSN: 1868-7083

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