Table 1 Characteristics and NDMI scores stratified by dexamethasone use (whole blood) or maternal risk factor (cord blood)
Study name/GEO series no | Immune profiles study (IPS)—pre-surgery glioma cases | Adult glioma study (AGS)—glioma cases | AGS—pilot cases | AGS—controls | GSE101840 | GSE152380 | GSE104376 | GSE153219 | GSE122288 | GSE122086 | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Platform | 850K | 850K | 850K, 450K | 850K | 450K | 450K | 450K | 450K | 850K | 850K | ||||||
Sample type | Whole blood | Whole blood | Whole blood | Whole blood | Cord blood | Cord blood | Cord blood | Cord blood | Cord blood | Cord blood | ||||||
Disease state | Pre-surgery, pre-treatment glioma patients | 195 IDH/1p19q/TERT-WT gliomas, 140 other gliomas | Pilot glioma cases | Adult non-glioma controls | Healthy newborn | Preterm birth | Pregnancy anxiety | Normal glucose tolerance (NGT) versus gestational diabetes mellitus (GDM) | Normal for glucose tolerance (NGT) | Gestational diabetes mellitus (GDM) | ||||||
Phenotype of interest | No DEX at blood draw | DEX at blood draw | No DEX at blood draw | DEX at blood draw | No DEX at blood draw | DEX at blood draw | No DEX at blood draw | Cord blood controls | Full-term newborn | Preterm newborn | Low anxiety | High anxiety | NGT | GDM | NGT | GDM |
N (missing phenotype) | 79 | 59 | 184 (1) | 150 | 6 | 6 | 447 (6) | 6 | 72 | 18 | 22 | 23 | 26 | 16 | 61 | 165 |
Age [years]/gestational age [weeks] (mean (SD)) | 47.18 (12.64) | 54.20 (17.18) | 50.80 (15.79) | 53.49 (14.33) | 46.67 (6.77) | 52.00 (2.76) | 51.84 (15.48) | NA | 34.77 (5.03) | 33.27 (6.49) | 39.61 (1.03) | 39.59 (1.46) | NA | NA | 38.74 (1.24) | 38.76 (1.22) |
Normal delivery | NA | NA | NA | NA | NA | NA | NA | 0 (0%) | 53 (74%) | 18 (10%) | 20 (90%) | 15 (65%) | NA | NA | NA | NA |
Sex | ||||||||||||||||
Female | 29 | 24 | 81 | 63 | 3 | 2 | 207 | 4 | 39 | 7 (39%) | 11 | 10 | 11 | 9 | 27 | 42 |
(col %) | (38%) | (41%) | (44%) | (42%) | (50%) | (33%) | (46%) | (67%) | (54%) | (39%) | (50%) | (43%) | (42%) | (56%) | (44%) | (25.5%) |
Male | 47 | 35 | 103 | 87 | 3 | 4 | 246 | 2 | 33 | 11 | 11 | 13 | 15 | 7 | 34 | 123 |
(col %) | (62%) | (59%) | (56%) | (58%) | (50%) | (67%) | (54%) | (33%) | (46%) | (61%) | (50%) | (57%) | (58%) | (44%) | (56%) | (74.5%) |
NDMI450 score (IQR) |  − 2.78 (− 3.63, − 2.04) | 3.27 (1.45, 4.61) |  − 1.45 (− 3.10, 0.34) | 2.24 (− 0.52, 4.33) |  − 3.23 (− 3.44, − 2.86) | 0.86 (− 0.33, 1.73) |  − 3.34 (− 4.39, − 2.23) |  − 5.79 (− 6.66, − 4.90) |  − 5.87 (− 6.76, − 4.76) |  − 7.52 (− 8.58, − 6.14) |  − 5.97 (− 7.57, − 4.96) |  − 5.18 (− 7.21, − 4.42) |  − 6.07 (− 6.98, − 4.97) |  − 5.43 (− 6.33, − 4.51) |  − 8.67 (− 9.15, − 8.30) |  − 8.71 (− 9.26, − 8.27) |
NDMI850 score (IQR) |  − 2.73 (− 3.60, − 1.94) | 2.72 (1.48, 4.15) |  − 1.45 (− 3.01, 0.19) | 1.49 (− 0.82, 3.36) |  − 2.31 (− 3.24, − 2.15) | 1.66 (0.90, 3.18) |  − 3.28 (− 4.23, − 2.08) | NA | NA | NA | NA | NA | NA | NA |  − 4.18 (− 5.19, − 3.30) |  − 4.3 (− 5.30, − 3.36) |