Fig. 1

Workflow. A Venn diagram demonstrating the neutrophil-specific CpG probes present on 450K and 850K platforms, the output of elastic net regression, and calculation of the linear composite score for NDMI 450 and NDMI 850. Of the 2621 neutrophil-specific probes of interest on the 850K array, 897 probes were available in the 450K. While for NDMI 850, elastic net chose 28 CpG probes as discriminative of DEX use, 22 were chosen for NDMI 450. 15 of these probes were shared between the two algorithms. The coefficients of the respective CpG probes were used to calculate the linear composite score (NDMI score) for each patient