Discovery | Replication | Meta-analysis | |||||||||
---|---|---|---|---|---|---|---|---|---|---|---|
CpG | CHR | BP | Gene | Feature | COEFF (UCI,LCI) | P | COEFF (UCI,LCI) | P | COEFF (UCI,LCI) | P | Direction |
cg00039070 | 7 | 133,482,303 | EXOC4 | Body | − 4.91(− 6.86,− 2.96) | 1.14E-06 | − 2.58(− 4.62,− 0.54) | 1.30E-02 | − 5.474(− 5.4738,− 5.4742) | 4.44E-08 | − − |
cg05979619 | 2 | 111,947,000 | MERTK | Body | − 6.21(− 8.16,− 4.26) | 9.72E-10 | − 1.26(− 3.24,0.72) | 2.15E-01 | − 5.250(− 5.2495,− 5.2501) | 1.54E-07 | − − |
cg10977834 | 4 | 77,075,687 | CCNI | 5'UTR | 4.85(6.80,2.90) | 1.53E-06 | 1.56(3.55,− 0.43) | 1.25E-01 | 4.875(4.8749,4.8747) | 1.11E-06 | + + |
cg08119231 | 1 | 220,747,874 | MOSC2 | TSS1500 | 5.01(6.96,3.06) | 7.07E-07 | 0.87(2.83,− 1.09) | 3.91E-01 | 4.871(4.8717,4.8704) | 1.11E-06 | + + |
cg21574204 | 6 | 28,081,180 | ZNF165 | 5'UTR | 4.72(6.67,2.77) | 2.88E-06 | 1.27(3.24,− 0.70) | 2.09E-01 | 4.847(4.8470,4.8470) | 1.21E-06 | + + |
cg01149259 | 3 | 46,979,906 | NBEAL2 | 1stExon | 4.68(6.63,2.73) | 3.48E-06 | 1.42(3.41,− 0.57) | 1.62E-01 | 4.768(4.7684,4.7682) | 1.86E-06 | + + |
cg18831371 | 5 | 176,610,324 | GPRIN1 | TSS200 | 5.35(7.30,3.40) | 1.25E-07 | 0.32(2.17,− 1.53) | 7.48E-01 | 4.752(4.7527,4.7522) | 2.02E-06 | + + |
cg26050512 | 20 | 58,981,011 | TH1L | TSS1500 | 4.83(6.78,2.88) | 1.71E-06 | − 0.09(− 1.93,1.75) | 9.30E-01 | 4.563(4.5626,4.5624) | 4.83E-06 | − + |
cg21404878 | 15 | 72,286,264 | BRUNOL6 | 3'UTR | 4.94(6.43,2.51) | 1.03E-06 | 0.02(2.19,− 2.15) | 6.69E-01 | 4.540(4.5407,4.5393) | 5.61E-06 | + + |
cg09548897 | 16 | 291,277 | AXIN1 | Body | − 4.69(− 6.64,− 2.74) | 3.37E-06 | − 0.73(− 2.67,1.21) | 4.69E-01 | − 4.499(− 4.4986,− 4.4989) | 6.80E-06 | − − |
cg14659930 | 3 | 114,409,454 | ZBTB20 | 5'UTR | 4.59(6.48,2.58) | 5.24E-06 | 0.19(2.08,− 1.70) | 3.78E-01 | 4.453(4.4544,4.4511) | 8.48E-06 | + + |
cg00939347 | 10 | 606,320 | DIP2C | Body | − 5.32(− 7.27,-3.37) | 1.45E-07 | − 0.5(− 2.42,1.42) | 6.22E-01 | − 4.450(− 4.4501,− 4.4506) | 8.50E-06 | − − |
cg07925823 | 16 | 68,264,601 | SLC7A6 | 5'UTR | 4.76(6.71,2.81) | 2.43E-06 | 1.4(3.39,− 0.59) | 1.68E-01 | 4.443(4.4430,4.4428) | 8.81E-06 | + + |
cg20383948 | 21 | 45,478,223 | COL18A1 | Body | 5.17(7.12,3.22) | 3.15E-07 | 0.97(2.93,− 0.99) | 3.38E-01 | 4.431(4.4307,4.4305) | 9.28E-06 | + + |
cg09741713 | 12 | 62,078,134 | FAM19A2 | 5'UTR | 4.66(6.63,2.73) | 3.82E-06 | − 1.12(− 3.08,0.84) | 5.20E-01 | 4.340(4.3408,4.3393) | 1.42E-05 | + + |
cg12103149 | 6 | 30,213,396 | TRIM26 | TSS200 | 4.56(6.58,2.68) | 6.06E-06 | 0.08(1.98,− 1.82) | 3.79E-01 | 4.331(4.3312,4.3311) | 1.45E-05 | + + |
cg10156941 | 17 | 1,563,002 | PITPNA | TSS200 | 4.67(6.62,2.72) | 3.63E-06 | 0.12(1.90,− 1.66) | 9.03E-01 | 4.349(4.3489,4.3488) | 1.46E-05 | + + |
cg15765398 | 21 | 44,990,079 | IGR | − 5.27(6.51,2.61) | 1.92E-07 | 0.89(2.85,− 1.07) | 1.60E-01 | − 4.328(− 4.3267,− 4.3288) | 1.51E-05 | + - | |
cg12349416 | 11 | 4,184,868 | IGR | 4.58(6.89,2.99) | 5.73E-06 | 0.43(2.32,− 1.46) | 4.84E-01 | 4.321(4.3219,4.3207) | 1.55E-05 | + + | |
cg14482313 | 12 | 52,233,105 | KRT7 | TSS200 | 4.60(6.55,2.65) | 5.19E-06 | 0.62(2.55,− 1.31) | 5.40E-01 | 4.304(4.3047,4.3037) | 1.68E-05 | + + |
cg02996131 | 6 | 152,637,463 | SYNE1 | TSS1500 | 4.60(6.61,2.71) | 5.08E-06 | 0.65(2.58,− 1.28) | 8.63E-01 | 4.252(4.2532,4.2516) | 2.11E-05 | + + |
cg19935850 | 4 | 41,751,422 | IGR | 4.99(6.94,3.04) | 7.94E-07 | − 0.14(− 1.91,1.63) | 8.86E-01 | 4.182(4.1825,4.1808) | 2.90E-05 | − + | |
cg10363284 | 4 | 8,005,411 | ABLIM2 | Body | − 5.54(-7.49,− 3.59) | 4.55E-08 | 0.29(2.18,− 1.60) | 7.76E-01 | − 4.179(− 4.1782,− 4.1790) | 2.94E-05 | + − |
cg18707780 | 15 | 99,733,585 | LYSMD4 | TSS200 | 4.46(6.41,2.51) | 9.75E-06 | − 0.41(− 2.31,1.49) | 6.85E-01 | 4.154(4.1539,4.1538) | 3.42E-05 | − + |
cg20648899 | 6 | 93,416,423 | EPHA7 | Body | 4.53(6.60,2.70) | 7.17E-06 | − 0.2(− 2.03,1.63) | 8.54E-01 | 4.007(4.0083,4.0057) | 6.14E-05 | + + |
cg07987148 | 20 | 46,690,251 | TP53RK | TSS1500 | 4.54(6.56,2.66) | 6.79E-06 | − 0.41(− 2.28,1.46) | 9.89E-01 | 3.980(3.9813,3.9790) | 6.88E-05 | - + |
cg07475390 | 1 | 14,114,109 | IGR | 4.68(6.53,2.63) | 3.52E-06 | 0.7(2.62,− 1.22) | 2.67E-01 | 3.959(3.9593,3.9580) | 7.55E-05 | - + | |
cg00347584 | 11 | 47,261,474 | NR1H3 | Body | 4.47(6.47,2.57) | 9.50E-06 | − 1.26(− 3.24,0.72) | 9.87E-01 | 3.909(3.9098,3.9081) | 9.27E-05 | + + |
cg13114315 | 21 | 36,174,169 | DOPEY2 | Body | 4.48(6.43,2.53) | 8.92E-06 | 0.49(2.41,− 1.43) | 6.30E-01 | 3.843(3.8438,3.8418) | 1.22E-04 | + + |
cg14414100 | 9 | 19,547,532 | SLC24A2 | Body | 4.63(6.59,2.69) | 4.55E-06 | − 0.56(− 2.46,1.34) | 9.40E-01 | 3.772(3.7733,3.7717) | 1.62E-04 | + + |
cg18795809 | 4 | 10,456,907 | ZNF518B | 5'UTR | 4.68(6.63,2.73) | 3.58E-06 | 0.34(2.22,− 1.54) | 7.36E-01 | 3.771(3.7708,3.7703) | 1.64E-04 | + + |
cg03732020 | 11 | 47,261,417 | NR1H3 | Body | 4.64(6.49,2.59) | 4.35E-06 | − 0.01(− 1.29,1.27) | 5.76E-01 | 3.551(3.5523,3.5506) | 3.83E-04 | − + |
cg24978805 | 7 | 3,687,557 | SDK1 | Body | − 4.84(− 6.79,− 2.89) | 1.67E-06 | − 0.35(− 2.24,1.54) | 7.30E-01 | − 3.184(− 3.1840,− 3.1845) | 1.45E-03 | − − |
cg08526825 | 16 | 2,752,228 | SRRM2 | TSS200 | 4.65(− 7.22,− 3.32) | 4.13E-06 | 1.43(3.42,-0.56) | 8.41E-01 | 3.051(3.0506,3.0504) | 2.28E-03 | − + |
cg25354926 | 4 | 818,823 | CPLX1 | Body | − 4.49(− 6.44,− 2.54) | 8.52E-06 | 0.95(2.91,− 1.01) | 3.47E-01 | − 2.784(− 2.7840,− 2.7844) | 5.37E-03 | +− |
cg04886221 | 1 | 27,343,238 | SYTL1 | 5'UTR | 4.61(6.55,2.65) | 4.97E-06 | 0.17(1.97,− 1.63) | 6.80E-01 | 2.532(2.5320,2.5319) | 1.14E-02 | − + |
cg22363670 | 7 | 86,643,853 | GRM3 | TSS200 | 4.49(6.44,2.54) | 8.55E-06 | − 0.3(− 2.16,1.56) | 7.65E-01 | 2.409(2.4095,2.4092) | 1.59E-02 | - + |
cg06933752 | 11 | 65,122,316 | FAU | TSS200 | 5.08(7.03,3.13) | 4.90E-07 | − 0.06(− 1.80,1.68) | 9.51E-01 | 2.199(2.1995,2.1994) | 2.80E-02 | − + |
cg04311230 | 6 | 159,693,649 | SOD2 | TSS1500 | 4.52(6.68,2.78) | 7.40E-06 | – | – | – | – | – |
cg04349420 | 8 | 48,501,719 | IGR | 4.73(6.66,2.76) | 2.79E-06 | – | – | – | – | – | |
cg07797073 | 1 | 2,051,352 | PRKCZ | Body | 4.71(− 6.61,− 2.71) | 3.02E-06 | – | – | – | – | – |
cg11491381 | 20 | 3,082,857 | AVP | Body | − 4.66(6.55,2.65) | 3.85E-06 | – | – | – | – | – |
cg18862005 | 2 | 177,076,135 | IGR | 4.60(6.56,2.66) | 5.10E-06 | – | – | – | – | – | |
cg25794823 | 18 | 63,949,347 | HMSD | TSS200 | 4.61(− 8.16,− 4.26) | 4.90E-06 | – | – | – | – | – |