Table 2 EWAS summary statistics in the Discovery, Replication and meta-analyses

cg00039070

7

133,482,303

EXOC4

Body

− 4.91(− 6.86,− 2.96)

1.14E-06

− 2.58(− 4.62,− 0.54)

1.30E-02

− 5.474(− 5.4738,− 5.4742)

4.44E-08

− −

cg05979619

2

111,947,000

MERTK

Body

− 6.21(− 8.16,− 4.26)

9.72E-10

− 1.26(− 3.24,0.72)

2.15E-01

− 5.250(− 5.2495,− 5.2501)

1.54E-07

− −

cg10977834

4

77,075,687

CCNI

5'UTR

4.85(6.80,2.90)

1.53E-06

1.56(3.55,− 0.43)

1.25E-01

4.875(4.8749,4.8747)

1.11E-06

 +  + 

cg08119231

1

220,747,874

MOSC2

TSS1500

5.01(6.96,3.06)

7.07E-07

0.87(2.83,− 1.09)

3.91E-01

4.871(4.8717,4.8704)

1.11E-06

 +  + 

cg21574204

6

28,081,180

ZNF165

5'UTR

4.72(6.67,2.77)

2.88E-06

1.27(3.24,− 0.70)

2.09E-01

4.847(4.8470,4.8470)

1.21E-06

 +  + 

cg01149259

3

46,979,906

NBEAL2

1stExon

4.68(6.63,2.73)

3.48E-06

1.42(3.41,− 0.57)

1.62E-01

4.768(4.7684,4.7682)

1.86E-06

 +  + 

cg18831371

5

176,610,324

GPRIN1

TSS200

5.35(7.30,3.40)

1.25E-07

0.32(2.17,− 1.53)

7.48E-01

4.752(4.7527,4.7522)

2.02E-06

 +  + 

cg26050512

20

58,981,011

TH1L

TSS1500

4.83(6.78,2.88)

1.71E-06

− 0.09(− 1.93,1.75)

9.30E-01

4.563(4.5626,4.5624)

4.83E-06

− + 

cg21404878

15

72,286,264

BRUNOL6

3'UTR

4.94(6.43,2.51)

1.03E-06

0.02(2.19,− 2.15)

6.69E-01

4.540(4.5407,4.5393)

5.61E-06

 +  + 

cg09548897

16

291,277

AXIN1

Body

− 4.69(− 6.64,− 2.74)

3.37E-06

− 0.73(− 2.67,1.21)

4.69E-01

− 4.499(− 4.4986,− 4.4989)

6.80E-06

− −

cg14659930

3

114,409,454

ZBTB20

5'UTR

4.59(6.48,2.58)

5.24E-06

0.19(2.08,− 1.70)

3.78E-01

4.453(4.4544,4.4511)

8.48E-06

 +  + 

cg00939347

10

606,320

DIP2C

Body

− 5.32(− 7.27,-3.37)

1.45E-07

− 0.5(− 2.42,1.42)

6.22E-01

− 4.450(− 4.4501,− 4.4506)

8.50E-06

− −

cg07925823

16

68,264,601

SLC7A6

5'UTR

4.76(6.71,2.81)

2.43E-06

1.4(3.39,− 0.59)

1.68E-01

4.443(4.4430,4.4428)

8.81E-06

 +  + 

cg20383948

21

45,478,223

COL18A1

Body

5.17(7.12,3.22)

3.15E-07

0.97(2.93,− 0.99)

3.38E-01

4.431(4.4307,4.4305)

9.28E-06

 +  + 

cg09741713

12

62,078,134

FAM19A2

5'UTR

4.66(6.63,2.73)

3.82E-06

− 1.12(− 3.08,0.84)

5.20E-01

4.340(4.3408,4.3393)

1.42E-05

 +  + 

cg12103149

6

30,213,396

TRIM26

TSS200

4.56(6.58,2.68)

6.06E-06

0.08(1.98,− 1.82)

3.79E-01

4.331(4.3312,4.3311)

1.45E-05

 +  + 

cg10156941

17

1,563,002

PITPNA

TSS200

4.67(6.62,2.72)

3.63E-06

0.12(1.90,− 1.66)

9.03E-01

4.349(4.3489,4.3488)

1.46E-05

 +  + 

cg15765398

21

44,990,079

IGR

− 5.27(6.51,2.61)

1.92E-07

0.89(2.85,− 1.07)

1.60E-01

− 4.328(− 4.3267,− 4.3288)

1.51E-05

 + -

cg12349416

11

4,184,868

IGR

4.58(6.89,2.99)

5.73E-06

0.43(2.32,− 1.46)

4.84E-01

4.321(4.3219,4.3207)

1.55E-05

 +  + 

cg14482313

12

52,233,105

KRT7

TSS200

4.60(6.55,2.65)

5.19E-06

0.62(2.55,− 1.31)

5.40E-01

4.304(4.3047,4.3037)

1.68E-05

 +  + 

cg02996131

6

152,637,463

SYNE1

TSS1500

4.60(6.61,2.71)

5.08E-06

0.65(2.58,− 1.28)

8.63E-01

4.252(4.2532,4.2516)

2.11E-05

 +  + 

cg19935850

4

41,751,422

IGR

4.99(6.94,3.04)

7.94E-07

− 0.14(− 1.91,1.63)

8.86E-01

4.182(4.1825,4.1808)

2.90E-05

− + 

cg10363284

4

8,005,411

ABLIM2

Body

− 5.54(-7.49,−  3.59)

4.55E-08

0.29(2.18,− 1.60)

7.76E-01

− 4.179(− 4.1782,− 4.1790)

2.94E-05

 + −

cg18707780

15

99,733,585

LYSMD4

TSS200

4.46(6.41,2.51)

9.75E-06

− 0.41(− 2.31,1.49)

6.85E-01

4.154(4.1539,4.1538)

3.42E-05

− + 

cg20648899

6

93,416,423

EPHA7

Body

4.53(6.60,2.70)

7.17E-06

− 0.2(− 2.03,1.63)

8.54E-01

4.007(4.0083,4.0057)

6.14E-05

 +  + 

cg07987148

20

46,690,251

TP53RK

TSS1500

4.54(6.56,2.66)

6.79E-06

− 0.41(− 2.28,1.46)

9.89E-01

3.980(3.9813,3.9790)

6.88E-05

- + 

cg07475390

1

14,114,109

IGR

4.68(6.53,2.63)

3.52E-06

0.7(2.62,− 1.22)

2.67E-01

3.959(3.9593,3.9580)

7.55E-05

- + 

cg00347584

11

47,261,474

NR1H3

Body

4.47(6.47,2.57)

9.50E-06

− 1.26(− 3.24,0.72)

9.87E-01

3.909(3.9098,3.9081)

9.27E-05

 +  + 

cg13114315

21

36,174,169

DOPEY2

Body

4.48(6.43,2.53)

8.92E-06

0.49(2.41,− 1.43)

6.30E-01

3.843(3.8438,3.8418)

1.22E-04

 +  + 

cg14414100

9

19,547,532

SLC24A2

Body

4.63(6.59,2.69)

4.55E-06

− 0.56(− 2.46,1.34)

9.40E-01

3.772(3.7733,3.7717)

1.62E-04

 +  + 

cg18795809

4

10,456,907

ZNF518B

5'UTR

4.68(6.63,2.73)

3.58E-06

0.34(2.22,− 1.54)

7.36E-01

3.771(3.7708,3.7703)

1.64E-04

 +  + 

cg03732020

11

47,261,417

NR1H3

Body

4.64(6.49,2.59)

4.35E-06

− 0.01(− 1.29,1.27)

5.76E-01

3.551(3.5523,3.5506)

3.83E-04

− + 

cg24978805

7

3,687,557

SDK1

Body

− 4.84(− 6.79,− 2.89)

1.67E-06

− 0.35(− 2.24,1.54)

7.30E-01

− 3.184(− 3.1840,− 3.1845)

1.45E-03

− −

cg08526825

16

2,752,228

SRRM2

TSS200

4.65(− 7.22,− 3.32)

4.13E-06

1.43(3.42,-0.56)

8.41E-01

3.051(3.0506,3.0504)

2.28E-03

− + 

cg25354926

4

818,823

CPLX1

Body

− 4.49(− 6.44,− 2.54)

8.52E-06

0.95(2.91,− 1.01)

3.47E-01

− 2.784(− 2.7840,− 2.7844)

5.37E-03

 +−

cg04886221

1

27,343,238

SYTL1

5'UTR

4.61(6.55,2.65)

4.97E-06

0.17(1.97,− 1.63)

6.80E-01

2.532(2.5320,2.5319)

1.14E-02

− + 

cg22363670

7

86,643,853

GRM3

TSS200

4.49(6.44,2.54)

8.55E-06

− 0.3(− 2.16,1.56)

7.65E-01

2.409(2.4095,2.4092)

1.59E-02

- + 

cg06933752

11

65,122,316

FAU

TSS200

5.08(7.03,3.13)

4.90E-07

− 0.06(− 1.80,1.68)

9.51E-01

2.199(2.1995,2.1994)

2.80E-02

− + 

cg04311230

6

159,693,649

SOD2

TSS1500

4.52(6.68,2.78)

7.40E-06

–

–

–

–

–

cg04349420

8

48,501,719

IGR

4.73(6.66,2.76)

2.79E-06

–

–

–

–

–

cg07797073

1

2,051,352

PRKCZ

Body

4.71(− 6.61,− 2.71)

3.02E-06

–

–

–

–

–

cg11491381

20

3,082,857

AVP

Body

− 4.66(6.55,2.65)

3.85E-06

–

–

–

–

–

cg18862005

2

177,076,135

IGR

4.60(6.56,2.66)

5.10E-06

–

–

–

–

–

cg25794823

18

63,949,347

HMSD

TSS200

4.61(− 8.16,− 4.26)

4.90E-06

–

–

–

–

–