Differential methylation in EGLN1 associates with blood oxygen saturation and plasma protein levels in high-altitude pulmonary edema

Table 2 Methylation distribution and association analysis of differentially methylated CpG sites of EGLN1 in HAPE-p, HAPE-f, and HLs

Differential methylation sites	HAPE-p (n = 26)	HLs (n = 24)	HAPE-f (n = 26)	HAPE-f versus HAPE-p			HLs versus HAPE-p			HAPE-f versus HLs
Differential methylation sites	Distribution (%)			\(\chi\)²	P*	OR (95% CI)	\(\chi\)²	P*	OR (95% CI)	\(\chi\)²	P*	OR (95% CI)
231,556,748	57.70	87.50	96.20	7.07	0.004	8.33 (2.15–156.58)	4.96	0.178	5.13 (1.22–21.63)	1.14	0.919	8.57 (0.35–36.94)
231,556,804	53.80	91.70	92.30	7.80	0.011	10.29 (2–52.79)	7.19	0.027	9.43 (1.83–48.61)	0.01	0.836	1.09 (0.14–8.42)
231,556,843	34.60	66.70	61.50	3.68	0.15	3.02 (0.98–9.36)	4.94	0.129	3.78 (1.17–12.19)	0.14	0.35	0.8 (0.25–2.55)
231,556,858	34.60	70.80	57.70	2.73	0.075	2.58 (0.84–7.91)	6.24	0.96	4.59 (1.39–15.15)	0.93	0.811	0.56 (0.17–1.82)
231,556,881	61.50	87.50	88.50	4.55	0.048	4.79 (1.14–20.21)	4.01	0.214	4.38 (1.03–18.56)	0.01	0.08	1.1 (0.2–6.03)
231,557,315	61.50	70.80	84.60	3.33	0.012	3.44 (0.91–12.95)	0.48	0.779	1.52 (0.47–4.95)	1.34	0.475	2.27 (0.57–9.02)
231,557,317	57.70	70.80	88.50	5.58	0.022	5.62 (1.34–23.56)	0.93	0.585	1.78 (0.55–5.77)	2.28	0.413	3.16 (0.71–14.02)
231,557,329	46.20	70.80	84.60	7.68	0.006	6.42 (1.72–23.9)	3.04	0.081	2.83 (0.88–9.13)	1.34	0.569	2.27 (0.57–9.02)
231,557,493	69.20	91.70	88.50	2.70	0.041	3.41 (0.79–14.72)	3.47	0.54	4.89 (0.92–25.97)	0.14	0.992	0.7 (0.11–4.58)

P*, P values obtained after adjusting it with age and gender by multinomial logistic regression analysis using SPSS 16.0 software. The methylation distributions were compared by the χ² test.
n Number of samples, (%) Percent distribution, OR Odds ratio, CI Confidence interval

ISSN: 1868-7083