Table 3 Sputum DNA methylation-based liquid biopsy for LC
Purpose | Genes | Cases | Controls | Sensitivity/specificity | Samples | Methods | References |
|---|---|---|---|---|---|---|---|
Diagnosis | RASSF1A/3OST2/PRDM14 | 232 | 240 | 82.2/66.3% | Sputum | qMSP | [67] |
Diagnosis | RASSF1A/3OST2/PRDM14 | 261 | 345 | 82.9/76.4% | Sputum | qMSP | [59] |
Diagnosis | RASSF1A/APC/CYGB | 161 | 536 | 63.0/78.0% in set 1 90.0/47.0% in set 2 | Sputum | qMSP | [64] |
Diagnosis | SOX17/TAC1/HOXA7 | 150 | 60 | 93.0/89.0% | Sputum | qMSP | [68] |
Assessment | P16/MGMT/DAPK/RASSF1A/GATA4/ GATA5/PAX5α/PAX5β | 371 | 1063 | 95.0/54.0% | Sputum | MSP | [60] |
Assessment | PAX5β/MGMT/DAPK/Dal-1/PCDH20/Jph3/Kif1a | 64 | 64 | –/– | Sputum | qMSP | [69] |
Assessment | PAX5α/DAPK/SULF2/PAX5β/CXCL14/ GATA5/Dal-1 | 40 | 90 | –/– | Sputum | qMSP | [69] |
Assessment | ZNF549/SNCA/CCNA1 | 29 | 108 | –/– | Sputum | MSP | [70] |