Fig. 2

Aberrant gain and loss of 5hmC coexist in genitourinary cancers and are associated with different oncogenic pathways. A Bar plot displaying numbers of hyper- and hypo-DhMRs identified in kidney, prostate and urothelial tumors compared with healthy controls. B, C Heatmaps showing the clustering of normal genitourinary samples based on hypo-DhMRs (B) and the clustering of genitourinary tumors based on hyper-DhMRs (C). Colors indicate normalized read counts of hMeDIP-seq. D–F Genome browser tracks depicting 5hmC levels of hypo (left)- and hyper-DhMRs (right) in kidney cancer (D), prostate cancer (E) and urothelial cancer (F). G–I Functional significance of hypo- and hyper-DhMRs of kidney cancer (G), prostate cancer (H) and urothelial cancer (I)