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Fig. 8 | Clinical Epigenetics

Fig. 8

From: JIB-04, a histone demethylase Jumonji C domain inhibitor, regulates phenotypic switching of vascular smooth muscle cells

Fig. 8

JIB-04 inhibited the proliferation, migration, and contractile phenotype of HASMCs by blocking autophagic flux and probably regulated the neointima. JIB-04, an inhibitor of Jumonji C domain-containing demethylases (JMJDs), induced cell cycle arrest in G2/M phase and inhibited the proliferation, migration, and contractile phenotype of HASMCs by regulating the methylation of H3K36. In addition, JIB-04 inhibited the fusion of autophagosomes and lysosomes by downregulating STX17 and RAB7, which further restrained the proliferation, migration, and contractile phenotype of HASMCs, ultimately protecting against neointima formation. Created by Biorender.com

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Clinical Epigenetics

ISSN: 1868-7083

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