Fig. 4
Mutations of ARID gene family. a Schematic illustration of KCDCOMs structure: KMT2C, KMT2D, p300 (encoded by EP300) and ARID family are components of KCDCOMs. KMT2C/KMT2D are involved in the methylation of H3K4, p300 regulates H3K27 acetylation, and ARID family participates in chromatin remodeling. The activated KCDCOMs can promote transcription. b Waterfall plot of mutations in ARID family. c The variant allele frequency of mutations in ARID family. d The PFS of patients with ARID gene family mutations is significantly shorter than patients without ARID gene mutations. e The OS of patients with ARID gene family mutations is significantly shorter than patients without ARID gene mutations