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Fig. 3 | Clinical Epigenetics

Fig. 3

From: Discovery and validation of tissue-specific DNA methylation as noninvasive diagnostic markers for colorectal cancer

Fig. 3

Discovery of specific methylation-based markers. A A process for identification of candidate DNA methylation-based markers of CRC. B Unsupervised hierarchical clustering of ten methylation-based markers selected for the diagnosis of CRC in the 45 TCGA paired CRC samples. C Unsupervised hierarchical clustering of ten methylation-based markers in 840 blood leukocytes of healthy individuals. D Unsupervised hierarchical clustering of ten methylation-based markers in 4525 tumor and normal tissues of ten other cancer types

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