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Table 3 CpG sites with significant changes in percent methylation as a function of menopause and treatment groups

From: Effect of menopausal hormone therapy on methylation levels in early and late postmenopausal women

CpG

aChr:pos

Nearest gene (location)

Early/Placebo (n = 48)

Early/Treatment (n = 48)

Late/Placebo (n = 42)

Late/Treatment (n = 48)

bP-int

cg19552895

12:49379205

WNT1 (S_Shelf)

− 0.8

− 0.6

− 1.2

1.7

1.1 × 10–9

cg18515510

19:7831896

CLEC4M (3' UTR)

0.4

− 0.2

0.6

1.9

2.4 × 10–8

  1. Data are shown as the mean change in methylation levels (%) between baseline and 36 months after treatment (calculated as post–pre) for the four treatment groups
  2. aChromosome and position (base pair) are based on build 37 (hg19) of the human genome reference sequence
  3. bp-values are derived from tests of interaction between time-since-menopause and HT using M-values for methylation with adjustment for age, ethnicity, and estimated blood cell fractions
  4. S_Shelf, southern shelf region that is directly adjacent to a southern shore, which is directly downstream of a CpG island
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Clinical Epigenetics

ISSN: 1868-7083

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