Relative contributions of six lifestyle- and health-related exposures to epigenetic aging: the Coronary Artery Risk Development in Young Adults (CARDIA) Study

Table 3 Relative contributions of six components to GrimAA at Y20 from QGC and BKMR by subgroups

Lifestyle components at or by Y20	Weights from QGC		PIPs from BKMR
By smoking status	Ever smokers (N = 285)	Never smokers (N = 459)	Ever smokers (N = 285)	Never smokers (N = 459)
Alcohol consumption	0.361	0.405	0.868	0.429
Diet quality	− 0.445	− 0.762	0.471	0.203
Education years	− 0.555	− 0.238	0.676	0.086
Physical activity	0.071	0.325	0.135	0.142
Sleep hours	0.007	0.270	0.138	0.119
Smoking	0.559	NA	1.000	NA
Collective association	1.47 (95% CI 0.39, 2.55), p = 0.008	0.13 (95% CI − 0.43, 0.71), p = 0.639	3.08 (95% CrI 1.13, 5.02)	0.47 (95% CrI − 0.38, 1.32)

By sex	Men (N = 391)	Women (N = 353)	Men (N = 391)	Women (N = 353)
Alcohol consumption	0.136	0.093	0.995	0.401
Diet quality	− 0.224	− 0.692	0.012	0.617
Education years	− 0.776	− 0.267	0.061	0.193
Physical activity	0.032	0.005	0.109	0.016
Sleep hours	0.034	− 0.036	0.053	0.055
Smoking	0.798	0.907	1.000	1.000
Collective association	6.67 (95% CI 5.43, 7.91), p < 0.001	3.18 (95% CI 1.92, 4.44), p < 0.001	5.53 (95% CrI 3.78, 7.27)	2.52 (95% CrI 0.74, 4.28)

By race	Black participants (N = 304)	White participants (N = 440)	Black participants (N = 304)	White participants (N = 440)
Alcohol consumption	0.168	0.082	0.993	0.292
Diet quality	− 0.477	− 0.423	0.032	0.425
Education years	0.034	− 0.577	0.063	0.821
Physical activity	− 0.523	0.061	0.001	0.410
Sleep hours	0.018	0.032	0.028	0.217
Smoking	0.780	0.824	1.000	1.000
Collective association	6.03 (95% CI 4.45, 7.61), p < 0.001	4.52 (95% CI 3.46, 5.58), p < 0.001	5.93 (95% CrI 3.24, 8.61)	1.96 (95% CrI 0.11, 3.81)

Models were adjusted for race, sex, body mass index (BMI), and field center; CI confidence interval, CrI credible interval, QGC Quantile-based g-computation, BKMR Bayesian kernel machine regression, PIPs posterior inclusion probabilities. The positive and negative weights from QGC represents the proportion of the effect estimate for each component (sum up to 1 or − 1 for the same direction); The PIP reflects the ranked importance of each component in association with GrimAA. † Change in mean GrimAA per one quartile change of all six components for QGC; change in mean GrimAA when all of the six lifestyle components are fixed at their 75th percentile compared to when the six lifestyle components are at their 25th percentile for BKMR

ISSN: 1868-7083