Fig. 5

(A) Histogram of the ICCs computed from the 17 samples assessed on both the 450 k and EPIC platforms. (B) Density distribution of mean difference in DNAm level, stratified by ICC category. (C) Density distribution of Pearson’s correlation coefficient, stratified by ICC category. The ICC categories are defined as follows: poor: ICC < 0.5; moderate: 0.5 ≤ ICC < 0.75; good: 0.75 ≤ ICC < 0.9; and excellent: ICC ≥ 0.9. The dark grey, dotted line indicates the median ICC, and the light grey, dotted line indicates the mean ICC. Outlying CpGs with ICCs less than the mean ICC minus three standard deviations were removed for visualisation purposes, but were included for summary statistic calculations