Cardiovascular health and four epigenetic clocks

Clinical Epigenetics

Table 3 Ideal CVH criterion (the 14-point CVH score)

	Poor: 0 point^a	Intermediate: 1 point^a	Ideal: 2 points^a
Lifestyle factors
Smoking status	Current	Former (quit < 6 months)	Never or former^b (quit ≥ 6 month)
Physical activity (regular exercise)^c	Never	Between never and regular	30 min 3 times a week (Regular exercise)
Ideal diet (Ideal diet score summed from Table S4)	0–5	6–11	12–17
Clinical factors
BMI (kg/m²)	BMI ≥ 27	24 ≤ BMI < 27	BMI < 24
Total cholesterol (mg/dL)	TC ≥ 240	200 ≤ TC < 240	TC < 200
Blood pressure level^d (mmHg)	SBP ≥ 140 or DBP ≥ 90	120 ≤ SBP < 140 or 80 ≤ DBP < 90	SBP < 120 and DBP < 80
Fasting glucose (mg/dL)	Fasting glucose ≥ 126	100 ≤ Fasting glucose < 126	Fasting glucose < 100

^aFor the 7-point CVH score, each component was scored as 1 if ideal, 0 if intermediate or poor
^bAccording to the TWB questionnaire, former smokers were defined as individuals who have quitted smoking for at least 6 months
^cRegular exercise was defined as performing exercise for 30 min at least 3 times a week. The exercise included leisure-time activities such as swimming, cycling, jogging, weight training, dancing, and mountain climbing, etc.
^dSBP Systolic blood pressure, DBP Diastolic blood pressure

ISSN: 1868-7083