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Fig. 8 | Clinical Epigenetics

Fig. 8

From: Genome-wide promoter methylation profiling in a cellular model of melanoma progression reveals markers of malignancy and metastasis that predict melanoma survival

Fig. 8

Genes from the metastasis signature with CpGs methylation status correlated with melanoma patient survival. The genes Arnt2, Igfbp4, and Ptprf are shown for gene expression (A, E and I, respectively) and CpG methylation (B, F and J, respectively) in melan-a, 4C, 4C11− and 4C11+ cell lines. C, F and K. Cell lines presenting, respectively, low Arnt2, Igfpb4 and Ptprf expression were treated for 48 h only with 5azaCdR or for additional 18 h with Trichostatin A (TSA) and had their expression evaluated by RT-qPCR. D, H and L. Kaplan–Meier plots show the result of overall survival analysis conducted in patients from the TCGA-SKCM cohort, with samples split by CpG methylation status for CpGs of the respective genes. Gene expression is shown as raw fragment counts, with the bar representing standard error

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Clinical Epigenetics

ISSN: 1868-7083

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