Fig. 2

Landscape of the transcriptomic and genetic alterations of histone modification regulators in colon cancer. A–D (left) Correlations, expressions, and prognosis of histone acetyltransferases (A, left), histone deacetylases (B, left), histone methyltransferases (C, left), and histone demethylase regulators (D, left) in patients with colon cancer. The red line represents a positive correlation with a p < 0.00001, and the blue line represents a negative correlation with a p < 0.00001. Yellow circles indicate a higher gene expression in colon cancer than in normal colon tissue. Blue circles indicate a lower gene expression in colon cancer than in normal colon tissue. Circle size represents the absolute value of the t-statistics obtained from the Student’s t test. The green points inside circles represent favorable factors for relapse-free survival, and the red points represent risk factors for relapse-free survival. A–D (right) The mutation frequency of histone acetyltransferases (A, right), histone deacetylases (B, right), histone methyltransferases (C, right), and histone demethylases regulators (D, right) in the TCGA-COAD cohorts. Each figure column represents one patient. The upper bar plot represents the total tumor mutation burden of patients. The number on the right shows the mutation frequency of each regulator. The right bar plot indicates the proportion of each variant type. E Matrix heatmap of the differential expression of histone modification regulators between the fluorouracil-response and fluorouracil-nonresponse groups. The expression of each histone modification regulator was compared by means of a two-sided Student’s t test. Red marked squares indicate higher expression in the fluorouracil-nonresponse group than in the fluorouracil-response group, and blue marked squares indicate higher expression in the fluorouracil-response group than in the fluorouracil-nonresponse group. *p < 0.05 and **p < 0.01