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Fig. 1 | Clinical Epigenetics

Fig. 1

From: Cross talk between acetylation and methylation regulators reveals histone modifier expression patterns posing prognostic and therapeutic implications on patients with colon cancer

Fig. 1

Workflow diagram of this study. The main steps conducted in the study were as follows: (1) the collection of histone modification regulators by searching published articles; (2) the identification of histone modifier expression patterns using an unsupervised clustering analysis; (3) the construction of the histone modification score by the Boruta dimension reduction algorithm; and (4) the identification of the driver genes mediating the fluorouracil resistance related to histone modifier expression patterns and the candidate targets or compounds for the chemosensitization of patients in the HMC4 cluster by conducting a genome-wide screening of the CRISPR-Cas9 library and a Connectivity Map analysis, respectively

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Clinical Epigenetics

ISSN: 1868-7083

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