Fig. 1

Summary of genetic and epigenetic alterations in BE (n = 19) and EAC (n = 145) samples. TP53 silent mutations with no amino acid change are not presented as alterations. In one sample (patient 83), two TP53 missense mutations were found. All samples with no or a low percentage of tumor cells (< 5%; n = 37) have been removed from the main data set (see Fig. 2), and the molecular alterations found in these samples are shown separately in the gray box. These samples were not used for determination of alterations frequencies. (*For MSI, the percentage refers to MSI-H tumors only.)