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Table 2 Total and indirect effects of adult pack years on health outcomes (N = 2978)

From: Lifetime exposure to smoking, epigenetic aging, and morbidity and mortality in older adults

Outcome Total effect 95% confidence interval
Panel A. Total effects of adult pack years on health outcomes
Mortality 0.0006 0.0000 0.0012
Cancer 0.0019 0.0003 0.0036
High blood pressure 0.0009 − 0.0001 0.0018
Lung disease 0.0029 0.0020 0.0038
Heart disease 0.0013 − 0.0001 0.0026
Outcome Mediator(s) Indirect effect 95% confidence interval
Panel B. Indirect effects of adult pack years on health outcomes—GrimAgeAdj
Mortality GrimAgeAdj 0.0005 0.0003 0.0008
Cancer GrimAgeAdj 0.0006 0.0001 0.0010
High blood pressure GrimAgeAdj 0.0012 0.0007 0.0017
Lung disease GrimAgeAdj 0.0011 0.0006 0.0015
Heart disease GrimAgeAdj 0.0010 0.0005 0.0015
Panel C. Indirect effects of adult pack years on health outcomes—PhenoAgeAdj
Mortality PhenoAgeAdj 0.0001 0.0000 0.0002
Cancer PhenoAgeAdj 0.0001 0.0000 0.0002
High blood pressure PhenoAgeAdj 0.0001 0.0000 0.0003
Lung disease PhenoAgeAdj 0.0000 0.0000 0.0001
Heart disease PhenoAgeAdj 0.0001 0.0000 0.0002
Panel D. Indirect effects of adult pack years on health outcomes—DunedinPoAm38Adj
Mortality DunedinPoAm38Adj 0.0004 0.0002 0.0006
Cancer DunedinPoAm38Adj 0.0005 0.0001 0.0008
High blood pressure DunedinPoAm38Adj 0.0007 0.0003 0.0012
Lung disease DunedinPoAm38Adj 0.0005 0.0001 0.0009
Heart disease DunedinPoAm38Adj 0.0005 0.0001 0.0009