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Table 4 The association between DMPs related to maternal sleep midpoint during late pregnancy and offspring adiposity indicators at 2 years old in the SSBC samplea

From: The mediating effect of DNA methylation in the association between maternal sleep during pregnancy and offspring adiposity status: a prospective cohort study

 

BMI (N = 191)

SF (N = 169)

Coef. (95% CI)

p

Coef. (95% CI)

p

Maternal sleep midpoint-related DMPs (gene)

cg04351668 (MARCH9)

2.96 (− 1.40, 7.32)

0.182

33.21 (13.92, 52.51)

0.001

cg04783204 (SLC29A1)

4.81 (− 9.11, 18.73)

0.496

101.68 (39.71, 163.65)

0.001

cg04794832 (RHBDL3)

8.76 (− 8.13, 25.65)

0.307

99.36 (28.98, 169.74)

0.006

cg08743881 (NLK)

2.63 (− 6.36, 11.61)

0.565

48.24 (5.91, 90.57)

0.026

cg09951570 (C14orf147)

1.54 (− 12.85, 15.92)

0.833

69.99 (3.18, 136.79)

0.040

cg14898140 (KPNA2)

4.85 (− 6.51, 16.21)

0.401

66.54 (15.14, 117.94)

0.011

cg14935078 (ABHD8)

3.46 (− 2.63, 9.54)

0.264

31.70 (4.17, 59.22)

0.024

cg17427781 (DDX20)

3.69 (− 5.56, 12.95)

0.432

58.40 (18.53, 98.26)

0.004

cg18310007 (EME1)

4.72 (− 13.69, 23.13)

0.614

102.58 (20.23, 184.93)

0.015

cg12232388

8.72 (1.52, 15.92)

0.018

74.80 (43.36, 106.24)

 < 0.001

cg12225226

 − 7.90 (− 13.66, − 2.14)

0.007

3.00 (− 22.05, 28.04)

0.813

cg18489012 (SFRS3)

 − 17.41 (− 32.12, − 2.70)

0.021

 − 12.82 (− 80.33, 54.69)

0.708

  1. BMI body mass index; DMPs differential methylated probes; SF subcutaneous fat; SSBC Shanghai sleep birth cohort
  2. aAdjusted for maternal age, education level, pre-pregnancy BMI, gestational weight gain, and offspring’s sex
  3. The bold values indicate statistical significance of p < 0.05