Characterising sex differences of autosomal DNA methylation in whole blood using the Illumina EPIC array

Clinical Epigenetics

Table 1 Enriched GO terms among the 54,261 CpGs identified to be significantly associated with sex

Path	Description	N	DE	P.DE	FDR
path:hsa04020	Calcium signalling pathway	240	192	4.10E−09	1.41E−06
path:hsa04015	Rap1 signalling pathway	210	169	1.15E−07	1.98E−05
path:hsa05200	Pathways in cancer	531	382.8333	1.91E−07	2.19E−05
path:hsa04014	Ras signalling pathway	232	180	2.97E−07	2.56E−05
path:hsa04010	MAPK signalling pathway	294	223.33333	2.24E−06	0.00015382
path:hsa04360	Axon guidance	182	148.5	3.46E−06	0.00019826
path:hsa04072	Phospholipase D signalling pathway	148	121	4.51E−06	0.00022149
path:hsa04310	Wnt signalling pathway	166	129.5	7.50E−05	0.00322397
path:hsa04371	Apelin signalling pathway	139	107.5	0.00011119	0.00363348
path:hsa04724	Glutamatergic synapse	114	93	0.00011675	0.00363348
path:hsa04390	Hippo signalling pathway	157	123.5	0.00012001	0.00363348
path:hsa01521	EGFR tyrosine kinase inhibitor resistance	79	67.5	0.00013811	0.00363348
path:hsa04071	Sphingolipid signalling pathway	119	94.5	0.00013944	0.00363348
path:hsa05226	Gastric cancer	149	115.5	0.00014787	0.00363348
path:hsa04550	Signalling pathways regulating pluripotency of stem cells	143	108.5	0.00059275	0.01359379
path:hsa04151	PI3K-Akt signalling pathway	354	245	0.00076003	0.01634056
path:hsa05224	Breast cancer	147	111.5	0.00092102	0.01863701
path:hsa04725	Cholinergic synapse	113	88	0.00148428	0.02836619
path:hsa04961	Endocrine and other factor-regulated calcium reabsorption	53	44	0.00209794	0.03798375
path:hsa05225	Hepatocellular carcinoma	168	123.5	0.00284431	0.04892215

N indicates the number of genes in the KEGG term. DE refers to the number of genes annotated to the sex-associated DMPs which are differentially methylated. P.DE indicates the P value for over representation of the KEGG term in this data set. FDR indicates the false discovery rate (using the Benjamini and Hochberg method)

ISSN: 1868-7083