Epigenetics of early-life adversity in youth: cross-sectional and longitudinal associations

Clinical Epigenetics

Table 3 Probes in candidate genes significantly associated with lifetime experience of abuse and neglect at baseline in cross-sectional analyses

Gene	Probe	Model	Coefficient (SE)	FDR^a
Lifetime experience of abuse
CRHR1	cg16830379	1^b	− 0.015 (0.004)	.010
CRHR1	cg16830379	3^d	− 0.015 (0.004)	.013
OXTR	cg03710862	2^c	− 0.020 (0.006)	.013
OXTR	cg03710862	4^e	− 0.019 (0.006)	.018
BDNF	cg25928860	3^f	− 0.031 (0.009)	.043
Lifetime experience of neglect
OXTR	cg03710862	5^f	0.018 (0.005)	.022
OXTR	cg03710862	6^g	0.018 (0.005)	.021
FKBP5	cg03098337	1^b	− 0.009 (0.002)	.014
FKBP5	cg03098337	3^d	− 0.008 (0.002)	.045
FKBP5	cg03098337	5^f	− 0.010 (0.003)	.009
FKBP5	cg03098337	6^g	− 0.010 (0.003)	.022

Chr chromosome, FDR false discovery rate, SE standard error
^aProbes significant at FDR < .05
^bModel 1 adjusted for age and income-to-needs ratio at baseline, sex, first five cell-type principal components, first five ancestry principal components, and random batch effects of DNA methylation measurement
^cModel 2 adjusted for Model 1 covariates and lifetime neglect
^dModel 3 adjusted for Model 1 covariates and tobacco use
^eModel 4 adjusted for Model 2 covariates and tobacco use
^fModel 5 adjusted for Model 1 covariates and lifetime abuse
^gModel 6 adjusted for Model 5 covariates and tobacco use

ISSN: 1868-7083