Epigenome-wide DNA methylation profiling of conditioned pain modulation in individuals with non-specific chronic low back pain

Table 3 Top 10 differentially hypo- and hypermethylated CpGs associated with CPM efficiency in pain-free control adults

Chr	Position	p-value	q-value	Methylation difference	Genes
Hypomethylated CpGs
7	36183317	3.96E−107	7.48E−102	− 30.15	EEPD1
17	50526142	1.21E−89	1.14E−84	− 27.10	EPN3
9	37944491	4.64E−63	2.92E−58	− 30.28	SLC25A51
1	30729051	1.19E−60	5.64E−56	− 31.59	MATN1
17	82551092	6.69E−56	2.11E−51	− 25.58	FOXK2
2	4964659	2.73E−50	5.74E−46	− 14.72	LINC01249
3	13406593	1.70E−49	2.92E−45	− 18.68	NUP210
2	148201344	8.69E−49	1.26E−44	− 15.33	LOC105373673
13	68877143	1.14E−48	1.53E−44	− 21.58	LINC02342
11	23941356	3.49E−48	4.40E−44	− 22.50	LINC02726
Hypermethylated CpGs
20	48625774	7.43E−58	2.81E−53	18.09	LOC105372646
2	9306946	1.95E−51	5.27E−47	20.47	ASAP2
1	147078143	1.05E−50	2.49E−46	27.79	LOC105371231
15	93041590	9.83E−50	1.86E−45	4.39	RGMA
1	24207420	5.60E−49	8.83E−45	19.93	LINC02800
7	98297732	3.63E−47	4.29E−43	20.61	BRI3
13	98064461	7.26E−45	8.07E−41	19.89	LOC107984566
19	2803229	2.72E−43	2.71E−39	19.42	THOP1
20	30283700	2.82E−40	2.32E−36	14.77	LINC01597
9	92254925	3.84E−36	2.50E−32	15.40	MIR3651
20	48625774	7.43E−58	2.81E−53	18.09	LOC105372646

ISSN: 1868-7083