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Table 1 Baseline demographic data

From: Epigenome-wide DNA methylation profiling of conditioned pain modulation in individuals with non-specific chronic low back pain

 

Deficient CPM

(n = 41)

Efficient CPM

(n = 57)

p-value

Pain status

   

 cLBP

20 (48.8)

30 (50.8)

0.84$

 PFCs

21 (51.2)

29 (49.2)

 

Chronic low back pain

N = 20

N = 28

 

Mean age (SD, years)

44.50 (14.21)

44.54 (12.25)

0.93*

Sex (n, %)

   

 Male

9 (45)

12 (42.9)

0.88$

 Female

11 (55)

16 (57.1)

 

Race (n, %)

   

 Black

9 (45)

13 (46.4)

0.92$

 White

11 (55)

15 (53.6)

 

Mean CPM (SD)

− 15.75 (12.71)

31.11 (23.02)

< 0.001*

Mean pain severity (SD)

4.20 (1.98)

4.66 (2.61)

0.56*

Mean pain interference (SD)

3.31 (2.33)

3.23 (2.57)

0.88*

Pain free controls

N = 21

N = 29

 

Age (Mean, SD)

41.80 (16.14)

38.61 (13.64)

0.46*

Sex (n, %)

  

0.54$

 Male

12 (57.1)

14 (48.3)

 

 Female

9 (42.9)

15 (51.7)

 

Race (n, %)

  

0.77$

 Black

10 (47.6)

15 (51.7)

 

 White

11 (52.4)

14 (48.3)

 

Mean CPM (SD)

− 14.96 (12.73)

17.51 (14.63)

< 0.001*

Mean pain severity (SD)

–

–

 

Mean pain interference (SD)

–

–

 
  1. cLBP, chronic low back pain; PFC, pain free control; CPM, conditioned pain modulation; SD, standard deviation
  2. *Mann–Whitney U Test; $Pearson’s Chi-Square Test
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Clinical Epigenetics

ISSN: 1868-7083

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