Fig. 2
From: Multi-omic alterations of the SWI/SNF complex define a clinical subgroup in lung adenocarcinoma
Clinical analyses with the mutational status of the lung SWI/SNF complex (A) Tumor mutation burden (TMB), defined as the number of non-silent mutations per Mb as estimated by Hoadley et al. [21], in SWI/SNF wild type vs SWI/SNF mutant patients in TCGA-LUAD. The red dot and lines represent the mean and standard deviation of the log10(TMB) values, respectively. A two-tailed Student's t test was performed on the log10(TMB) values. (B) Univariate Cox Proportional-Hazards regression on mutation and clinical covariates from TCGA-LUAD. All variables included in the model are sorted by statistical significance (p-value). (C) Kaplan–Meier curves grouping the TCGA-LUAD cohort by the mutational status of SWI/SNF complex (Logrank test). (D) Multivariate Cox Proportional-Hazards regression on mutation and clinical TCGA-LUAD covariates. All variables included are sorted by statistical significance (p-value)