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Fig. 5 | Clinical Epigenetics

Fig. 5

From: Transcriptional, epigenetic and metabolic signatures in cardiometabolic syndrome defined by extreme phenotypes

Fig. 5

Multi-omic signature classification of extreme phenotypes. a Presentation of the different layers used for multi-omic integration, the strategy leading to signature identification and schematic view of BD ranking. b Heatmaps showing the mean of the Z-score distribution for each group, for all features selected in each layer. c Plots showing individuals ranked by their predicted probability of belonging to the obese group, using models trained using data from individual layers, as well as a multi-layer predictive model (as indicated by the plot titles). Plots are ordered by decreasing log loss, with smaller values corresponding to better discrimination of individuals in the extreme phenotype group from all other individuals. d Heatmap showing age and sex adjusted association values between (left) eight prioritised lipid species and risk factors measured in the Fenland and present cohorts; and (right) a negative control set of five unselected lipid species and the same risk factors. Black asterisks indicate significant associations after correcting for multitesting

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