Fig. 1
From: Roles for the methyltransferase SETD8 in DNA damage repair
The methylation activity and regulatory network of SETD8. SETD8 monomethylates histone H4 to generate H4K20me1 on chromatin, a prerequisite for di- and tri-methylation catalyzed by SUV4-20h1 and SUV4-20h2 to produce H4K20me2 and H4K20me3, respectively. Conversely, PHF8 regulates the demethylation of H4K20me1. The levels of SETD8 are downregulated by the ubiquitin–proteasome system. The deubiquitinating enzyme USP17 is reported to stabilize SETD8 by removing polyubiquitin chains from (Ub)n-SETD8