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Fig. 5 | Clinical Epigenetics

Fig. 5

From: Atheroprotective mechanism by which folic acid regulates monocyte subsets and function through DNA methylation

Fig. 5

ARID5B suppresses the expression of CCR2, MCP-1, and TNF-α and the migration and adhesion of THP-1 cells. A The protein and mRNA expression of ARID5B in wild-type, ARID5B-overexpressing and ARID5B-knockout THP-1 cells. B Relative mRNA expression levels of CCR2, MCP-1, and TNF-α in THP-1 cells. C The migration capacity of THP-1 cells was assessed by Transwell migration assays with an inverted microscope (magnification × 100). D The adhesion of THP-1 cells to HUVECs was assessed using a fluorescence microscope (magnification × 100). All plotted values are the mean ± SE values of at least three independent experiments. WT, wild type; OE, overexpression; KO, knockout. *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001

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Clinical Epigenetics

ISSN: 1868-7083

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