Table 2 The 20 most differentially methylated regions between the high- and average-risk breast tissues
From: Aberrant epigenetic and transcriptional events associated with breast cancer risk
Genomic Locus | Overlapping Gene Feature | Gene Name | Description | ∆Z# | FDR |
|---|---|---|---|---|---|
Chr8:120,669,501 | Intron | SNTB1 | syntrophin beta 1 | 2.4 | 7E-53 |
Chr18:6,803,751 | Intron | ARHGAP28 | Rho GTPase activating protein 28 | 2.0 | 3E-35 |
Chr6:12,944,751 | Intron | PHACTR1 | phosphatase and actin regulator 1 | 1.9 | 1E-31 |
Chr21:30,743,501 | promoter | KRTAP21-4P | keratin associated protein 21–4 2C pseudogene | 1.9 | 6E-31 |
Chr2:115,663,751 | Intron | DPP10 | dipeptidyl peptidase like 10 | 1.8 | 2E-30 |
Chr4:87,111,001 | Intron | AFF1 | AF4/FMR2 family member 1 | 1.8 | 2E-29 |
Chr3:33,638,251 | Intron | CLASP2 | cytoplasmic linker associated protein 2 | 1.8 | 2E-29 |
Chr14:106,498,501 | Intron | LINC01881 | long intergenic non-protein coding RNA1881 | 1.8 | 2E-29 |
Chr6:129,416,001 | Intron | LAMA2 | laminin subunit alpha 2 | 1.8 | 4E-29 |
Chr14:31,750,251 | Intron | NUBPL | nucleotide binding protein like | 1.8 | 2E-28 |
Chr8:37,842,001 | Coding | ADGRA2 | adhesion G protein-coupled receptor A2 | − 1.2 | 1E-12 |
Chr1:44,724,501 | Coding | C1orf228 | chromosome 1 open reading frame 228 | − 1.2 | 9E-13 |
ChrX:46,575,001 | Coding | CHST7 | carbohydrate sulfotransferase 7 | − 1.2 | 5E-13 |
Chr14:104,729,501 | Coding | ADSSL1 | adenylosuccinate synthase like 1 | − 1.3 | 1E-15 |
Chr2:202,774,251 | Intron/promoter | ICA1L | islet cell autoantigen 1 like | − 1.3 | 1E-15 |
Chr1:155,190,001 | Coding | MUC1 | mucin 1, 2C cell surface associated | − 1.4 | 2E-17 |
Chr20:3,751,751 | Coding | HSPA12B | heat shock protein family A (Hsp70) member 12B | − 1.4 | 8E-18 |
Chr11:58,141,001 | Intron | OR9Q1 | olfactory receptor family 9 subfamily Q member 1 | − 1.6 | 4E-22 |
Chr1:45,803,751 | Coding | MAST2 | microtubule associated serine/threonine kinase 2 | − 1.6 | 3E-23 |
Chr7:636,001 | Intron | PRKAR1B | protein kinase cAMP-dependent type I regulatory subunit beta | − 1.7 | 1E-24 |