Epigenetics of single-site and multi-site atherosclerosis in African Americans from the Genetic Epidemiology Network of Arteriopathy (GENOA)

Table 3 Associations between epigenetic age acceleration and atherosclerosis measures in GENOA African-Americans

Outcome	Epigenetic age acceleration	Model 1			Model 2			Model 3
Outcome	Epigenetic age acceleration	Beta	SE	P	Beta	SE	P	Beta	SE	P
Coronary artery calcification score (CAC)^a	IEAA	0.016	0.027	0.555	0.008	0.026	0.750	− 0.008	0.025	0.741
	EEAA	0.018	0.023	0.436	0.012	0.022	0.589	0.003	0.021	0.901
	PhenoAA	0.034	0.018	0.056	0.023	0.017	0.191	0.010	0.017	0.532
	GrimAA	0.149	0.028	2.04 × 10^–7	0.105	0.034	0.002	0.074	0.033	0.025
Abdominal aorta calcification score (AAC)^a	IEAA	− 0.016	0.029	0.591	− 0.025	0.028	0.366	− 0.040	0.027	0.139
	EEAA	0.027	0.025	0.285	0.024	0.024	0.311	0.018	0.024	0.437
	PhenoAA	0.046	0.019	0.018	0.033	0.018	0.073	0.028	0.018	0.133
	GrimAA	0.188	0.031	2.94 × 10^–9	0.106	0.036	0.004	0.092	0.036	0.012
Ankle–brachial index (ABI)	IEAA	− 0.001	0.001	0.562	0	0.001	0.644	− 0.001	0.001	0.580
	EEAA	0	0.001	0.649	0	0.001	0.755	0	0.001	0.795
	PhenoAA	− 0.001	0.001	0.076	− 0.001	0.001	0.133	− 0.001	0.001	0.149
	GrimAA	− 0.004	0.001	0.002	− 0.003	0.001	0.024	− 0.003	0.001	0.026
Multi-site atherosclerosis score	IEAA	0.021	0.031	0.489	0.011	0.029	0.713	− 0.002	0.029	0.942
	EEAA	0.027	0.027	0.318	0.021	0.026	0.417	0.013	0.025	0.613
	PhenoAA	0.067	0.020	0.001	0.052	0.020	0.008	0.044	0.019	0.023
	GrimAA	0.231	0.032	4.59 × 10^–12	0.158	0.038	4.58 × 10^–5	0.140	0.038	3.01 × 10^–4

IEAA intrinsic epigenetic age acceleration, EEAA extrinsic epigenetic age acceleration, PhenoAA PhenoAge acceleration, GrimAA GrimAge acceleration
Model 1 is adjusted for age, sex, and time between measures
Model 2 is adjusted for Model 1 covariates and smoking status
Model 3 is adjusted for Model 2 covariates, hypertension status, diabetes status, body mass index, and total cholesterol levels adjusted for statin use
Beta is the change in the atherosclerosis measure associated with a 1 unit increase in the epigenetic age acceleration measure
P values significant after Bonferroni correction (P < 0.0125) are shown in bold font
^aCoronary artery and abdominal aorta calcification scores were transformed as ln[(CAC + 1)] and ln[(AAC + 1)]

ISSN: 1868-7083