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Table 4 Estimated coefficients (uncorrected and corrected) for the clinical + AgeAccelGrim model

From: Epigenetic biomarkers of ageing are predictive of mortality risk in a longitudinal clinical cohort of individuals diagnosed with oropharyngeal cancer

 

Original model

Final model after adjustment for overfitting

  

95% CI

 

95% CI

Variable

β

ll

ul

β

ll

ul

Age

0.05

0.02

0.07

0.04

0.02

0.06

Sex

      

Female

0.42

− 0.14

0.99

0.35

− 0.12

0.82

Tumour stage

      

II

0.64

− 1.56

2.85

0.53

− 1.29

2.36

III

1.65

− 0.38

3.69

1.37

− 0.32

3.06

IV

1.85

− 0.14

3.84

1.54

− 0.12

3.19

HPV status

      

Positive

− 0.95

− 1.47

− 0.44

− 0.79

− 1.22

− 0.36

Comorbidity*

      

Mild

0.33

− 0.23

0.90

0.28

− 0.19

0.75

Moderate/severe

0.24

− 0.38

0.85

0.20

− 0.31

0.70

AgeAccelGrim

0.52

0.26

0.78

0.43

0.22

0.65

  1. Regression coefficients (ß) and 95% confidence intervals (CI) for 3-year overall survival
  2. Hazard ratios can be obtained by exponentiating model estimates