Fig. 2

Epigenome-wide association analysis of high-density lipoprotein cholesterol in the Indian cohort. A Manhattan plot of EWAS results with respect to high-density lipoprotein cholesterol (HDL-C) levels in the Indian data. Red line indicates the FDR threshold of 0.05. Significant dmCpGs (FDR < 0.05) are highlighted in red and labelled with the gene associated with it. B Relationship between methylation beta value at cg04988216 (ROR1) and HDL-C residual (mmol/l) in 674 Indian children. Two outlier samples are highlighted in red. C Relationship between methylation beta value at cg04988216 (ROR1) and HDL-C residual (mmol/l) in 672 Indian children after removal of the two outlier samples highlighted in C. D Relationship between methylation at cg04988216 and HDL-C residuals (mmol/l) in the male and female children separately. Shaded area around the regression lines denotes the 95% confidence interval band. EWAS, Epigenome-wide association study