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Fig. 6 | Clinical Epigenetics

Fig. 6

From: Fibroblast growth factor (FGF), FGF receptor (FGFR), and cyclin D1 (CCND1) DNA methylation in head and neck squamous cell carcinomas is associated with transcriptional activity, gene amplification, human papillomavirus (HPV) status, and sensitivity to tyrosine kinase inhibitors

Fig. 6

Sensitivity to FGFR inhibitors in CCND1 (CpG 36) hyper- and hypomethylated HNSCC cell lines. Y-axis represents drug sensitivity [ln(IC50)] of HNSCC cell lines treated with FGFR inhibitors PD 173074 and AZD4547. The cell lines were classified as hypo- and hyper-methylated based on the median methylation levels. P values refer to Mann–Whitney U test

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Clinical Epigenetics

ISSN: 1868-7083

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