Fig. 4

TET1-coactivated transcription factors (TFs) in PCa. A Correlation matrix (Pearson) demonstrating the strongly correlated expression of TET1 and 161 genes encoding TFs in PCa. For TOP30 TET1-coactivated TFs (TF-encoding genes exhibiting the highest correlation with TET1), correlation matrices of gene expression (top triangle, Pearson), promoter methylation, and corresponding gene expression (black squares, Spearman; CpG probes in TSS1500 showing the most negative correlation with gene expression are indicated), and of promoter methylations (bottom triangle, Pearson; the methylation status of several promoters showed positive correlations) are shown; B 133 out of 161 TET1-coactivated TFs are zinc-finger TFs (highlighted in yellow), and in TET1-high PCa 68 showed at least one significantly demethylated CpG site within the TSS1500 promoter (hash mark; TET1-high versus TET1-low PCa, Benjamini–Hochberg method)