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Table 1 Shared gene ontology annotations for enrichment analyses on CpG probes that exhibited a β values difference > 0.1 before and after ionizing radiation of HepG2 and MeWo-LC1 cell lines

From: Ionizing radiations induce shared epigenomic signatures unraveling adaptive mechanisms of cancerous cell lines with or without methionine dependency

GO biological process complete HepG2* MeWo-LC1*
FE P-value FDR,
P-value
FE P-value FDR,
P-value
Blood circulation (GO:0008015) 3.22 2.22 × 10–5 2.34 × 10–2 2.33 7.49 × 10–5 1.62 × 10–2
Animal organ morphogenesis (GO:0009887) 2.34 1.19 × 10–5 1.71 × 10–2 1.97 1.58 × 10–6 8.04 × 10–4
Plasma membrane-bounded cell projection organization (GO:0120036) 2.26 3.86 × 10–6 7.63 × 10–3 1.73 2.98 × 10–5 8.27 × 10–3
Cell projection organization (GO:0030030) 2.23 5.33 × 10–6 8.42 × 10–3 1.72 2.86 × 10–5 8.07 × 10–3
Cell development (GO:0048468) 1.95 2.02 × 10–5 2.45 × 10–2 2.06 3.40 × 10–12 5.96 × 10–9
Anatomical structure morphogenesis (GO:0009653) 1.94 7.92 × 10–7 2.50 × 10–3 1.82 1.49 × 10–10 1.96 × 10–7
Nervous system development (GO:0007399) 1.86 4.60 × 10–6 8.08 × 10–3 1.94 1.67 × 10–13 3.31 × 10–10
Cell differentiation (GO:003054) 1.58 1.90 × 10–5 2.51 × 10–2 1.75 9.46 × 10–16 2.99 × 10–12
Cellular developmental process (GO:0048869) 1.58 2.13 × 10–5 2.40 × 10–2 1.75 6.11 × 10–16 2.41 × 10–12
System development (GO:0048731) 1.56 2.62 × 10–6 6.89 × 10–3 1.64 8.72 × 10–15 1.97 × 10–11
Multicellular organism development (GO:0007275) 1.55 4.60 × 10–7 1.82 × 10–3 1.61 5.24 × 10–16 2.76 × 10–12
Anatomical structure development (GO:0048856) 1.55 1.51 × 10–7 1.19 × 10–3 1.59 9.01 × 10–17 7.12 × 10–13
Developmental process (GO:0032502) 1.51 2.22 × 10–7 1.17 × 10–3 1.59 5.53 × 10–19 8.74 × 10–15
Multicellular organismal process (GO:0032501) 1.45 1.10 × 10–7 1.73 × 10–3 1.46 1.64 × 10–15 4.33 × 10–12
  1. FE: fold enrichment; DFR: false discovery rate
  2. * No significant GO annotation was found for the CpG probes that exhibited a β values difference > 0.1 before and after ionizing radiation for MeWo and U251 cell lines