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Table 1 Shared gene ontology annotations for enrichment analyses on CpG probes that exhibited a β values difference > 0.1 before and after ionizing radiation of HepG2 and MeWo-LC1 cell lines

From: Ionizing radiations induce shared epigenomic signatures unraveling adaptive mechanisms of cancerous cell lines with or without methionine dependency

GO biological process complete

HepG2*

MeWo-LC1*

FE

P-value

FDR,

P-value

FE

P-value

FDR,

P-value

Blood circulation (GO:0008015)

3.22

2.22 × 10–5

2.34 × 10–2

2.33

7.49 × 10–5

1.62 × 10–2

Animal organ morphogenesis (GO:0009887)

2.34

1.19 × 10–5

1.71 × 10–2

1.97

1.58 × 10–6

8.04 × 10–4

Plasma membrane-bounded cell projection organization (GO:0120036)

2.26

3.86 × 10–6

7.63 × 10–3

1.73

2.98 × 10–5

8.27 × 10–3

Cell projection organization (GO:0030030)

2.23

5.33 × 10–6

8.42 × 10–3

1.72

2.86 × 10–5

8.07 × 10–3

Cell development (GO:0048468)

1.95

2.02 × 10–5

2.45 × 10–2

2.06

3.40 × 10–12

5.96 × 10–9

Anatomical structure morphogenesis (GO:0009653)

1.94

7.92 × 10–7

2.50 × 10–3

1.82

1.49 × 10–10

1.96 × 10–7

Nervous system development (GO:0007399)

1.86

4.60 × 10–6

8.08 × 10–3

1.94

1.67 × 10–13

3.31 × 10–10

Cell differentiation (GO:003054)

1.58

1.90 × 10–5

2.51 × 10–2

1.75

9.46 × 10–16

2.99 × 10–12

Cellular developmental process (GO:0048869)

1.58

2.13 × 10–5

2.40 × 10–2

1.75

6.11 × 10–16

2.41 × 10–12

System development (GO:0048731)

1.56

2.62 × 10–6

6.89 × 10–3

1.64

8.72 × 10–15

1.97 × 10–11

Multicellular organism development (GO:0007275)

1.55

4.60 × 10–7

1.82 × 10–3

1.61

5.24 × 10–16

2.76 × 10–12

Anatomical structure development (GO:0048856)

1.55

1.51 × 10–7

1.19 × 10–3

1.59

9.01 × 10–17

7.12 × 10–13

Developmental process (GO:0032502)

1.51

2.22 × 10–7

1.17 × 10–3

1.59

5.53 × 10–19

8.74 × 10–15

Multicellular organismal process (GO:0032501)

1.45

1.10 × 10–7

1.73 × 10–3

1.46

1.64 × 10–15

4.33 × 10–12

  1. FE: fold enrichment; DFR: false discovery rate
  2. * No significant GO annotation was found for the CpG probes that exhibited a β values difference > 0.1 before and after ionizing radiation for MeWo and U251 cell lines