Prenatal metal exposure, cord blood DNA methylation and persistence in childhood: an epigenome-wide association study of 12 metals

Table 3 Summary of cord blood differentially methylated regions (Sidak p < 0.05) associated with individual metals

	All infants (N = 361)		Female (N = 169)		Male (N = 192)
	Number of DMRs	Genes	Number of DMRs	Genes	Number of DMRs	Genes
As	1	LOC144571	2	CAT	3	LDHC; LOC144571; OXT
Ba	0		2	GSDMD; VENTX	2	DDX60; LOC619207
Cd	4	HOXB7	2	HOXA11	3	HIST1H1A; SLC17A9
Cr	3	B3GALT4; DLC1; TCF7L2	2	DLC1	0
Cs	18	ZBTB38; CMYA5; VARS2; GTF2H4; PPP1R2P1; TAPBP; LYNX1; RAD52; PUS7L; IRAK4; ZNF385A; MIR548H4; NOX5; RAI1; SKAP1; SLC44A2; GNAS; GNASAS	3	STMN1; GOPC; IRAK4; PUS7L	14	ZBTB38; VARS2; GTF2H4; LRRC27; WSCD2; MIR548H4; NOX5; RAI1
Cu	3	INO80B; HNRPA1L-2; HNRNPA1; CBX5; GNAS; GNASAS	1	GNAS; GNASAS	6	NTNG1; PRSS50; HAPLN1; PPP1R2P1; HNRPA1L-2; HNRNPA1; CBX5
Hg ^a	2	RNF39; LYNX1	0		3	RNF39; LYNX1
Mg	5	FLJ42875; RNF39; TNXB; B4GALNT4; GNAS; GNASAS	3	CRIP2; WFIKKN2; GNAS; GNASAS	1	AURKC
Mn	1	TNXB	7	SUCLG2; HLTF; AGPAT4; CARD11; HOXA4; OXGR1	3	TTC23; BLCAP; NNAT
Pb	0		0		2	SEMA5B
Se	2	PF4; GSDMD	3	GSDMD; CYP1A1; ADAMTSL5	1	AURKC
Zn	5	COL7A1; MTNR1B; CACNA2D4; FSCN2; LOC284798	0		3	TMEM88B; MCC

Differentially methylated regions (DMRs) identified using models of individual log₂-transformed prenatal metal concentrations adjusted for infant sex, race/ethnicity, gestational age, nulliparous, maternal age at enrollment, pre-pregnancy BMI, education, smoking, household income, and estimated cord blood cell-type proportions
^aAll infants: N = 358; female: N = 167; male: N = 191

ISSN: 1868-7083