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Table 3 Summary of cord blood differentially methylated regions (Sidak p < 0.05) associated with individual metals

From: Prenatal metal exposure, cord blood DNA methylation and persistence in childhood: an epigenome-wide association study of 12 metals

  All infants (N = 361) Female (N = 169) Male (N = 192)
Number of DMRs Genes Number of DMRs Genes Number of DMRs Genes
As 1 LOC144571 2 CAT 3 LDHC; LOC144571; OXT
Ba 0   2 GSDMD; VENTX 2 DDX60; LOC619207
Cd 4 HOXB7 2 HOXA11 3 HIST1H1A; SLC17A9
Cr 3 B3GALT4; DLC1; TCF7L2 2 DLC1 0  
Cs 18 ZBTB38; CMYA5; VARS2; GTF2H4; PPP1R2P1; TAPBP; LYNX1; RAD52; PUS7L; IRAK4; ZNF385A; MIR548H4; NOX5; RAI1; SKAP1; SLC44A2; GNAS; GNASAS 3 STMN1; GOPC; IRAK4; PUS7L 14 ZBTB38; VARS2; GTF2H4; LRRC27; WSCD2; MIR548H4; NOX5; RAI1
Cu 3 INO80B; HNRPA1L-2; HNRNPA1; CBX5; GNAS; GNASAS 1 GNAS; GNASAS 6 NTNG1; PRSS50; HAPLN1; PPP1R2P1; HNRPA1L-2; HNRNPA1; CBX5
Hg a 2 RNF39; LYNX1 0   3 RNF39; LYNX1
Mg 5 FLJ42875; RNF39; TNXB; B4GALNT4; GNAS; GNASAS 3 CRIP2; WFIKKN2; GNAS; GNASAS 1 AURKC
Mn 1 TNXB 7 SUCLG2; HLTF; AGPAT4; CARD11; HOXA4; OXGR1 3 TTC23; BLCAP; NNAT
Pb 0   0   2 SEMA5B
Se 2 PF4; GSDMD 3 GSDMD; CYP1A1; ADAMTSL5 1 AURKC
Zn 5 COL7A1; MTNR1B; CACNA2D4; FSCN2; LOC284798 0   3 TMEM88B; MCC
  1. Differentially methylated regions (DMRs) identified using models of individual log2-transformed prenatal metal concentrations adjusted for infant sex, race/ethnicity, gestational age, nulliparous, maternal age at enrollment, pre-pregnancy BMI, education, smoking, household income, and estimated cord blood cell-type proportions
  2. aAll infants: N = 358; female: N = 167; male: N = 191