Associations between DNA methylation and BMI vary by metabolic health status: a potential link to disparate cardiovascular outcomes

Table 3 Significant CpG sites associated with incident coronary heart disease (CHD) in the Women’s Health Initiative (WHI) over 25 years

CpG site	Hazard ratio	95% CI	P value
cg02851049^a	0.90	(0.81, 0.99)	0.030
cg20210586^a	1.09	(1.00, 1.19)	0.046
cg16461485^a	0.94	(0.89, 0.99)	0.031
cg16461485^b	0.93	(0.88, 0.99)	0.023
cg16543390^b	1.06	(1.01, 1.11)	0.028

Cox proportional hazard model examining the association between incident CHD and β value of the 22 CpG sites in discovery analysis. Models adjusted for age, race/ethnicity, smoking status, case–control status (BAA23 and AS311), DNA methylation array, row, and cell composition in reduced model^a and reduced model covariates and physical activity and diet in the full model^b

ISSN: 1868-7083