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Table 1 Demographic characteristics of each ancillary study in the Women’s Health Initiative (WHI) and the Atherosclerosis Risk in Communities (ARIC)

From: Associations between DNA methylation and BMI vary by metabolic health status: a potential link to disparate cardiovascular outcomes

  EMPC (n = 1833) BAA23 (n = 1977) AS311 (n = 167) ARIC EA (n = 1059) ARIC AA (n = 2461)
Clinical trial participant
 Yes 1833 1543 119
 No 0 434 48
Case/control status
 Case 987 91
 Control 990 76
Age mean (SD) 63.2 (7.1) 64.6 (7.1) 66.2 (7.2) 59.9 (5.4) 56.6 (5.9)
Sex
 Female 1833 1977 167 611 1574
 Male 0 0 0 448 887
Ethnicity
 White 922 944 99 1059 0
 African American 474 631 49 0 2461
 Hispanic/Latino 260 402 16 0 0
 Asian or Pacific Islander 107 0 2 0 0
 American Indian or Alaskan Native 41 0 1 0 0
 Other 29 0 0 0 0
Smoking status
 Former and current 853 913 99 610 1351
 Never 963 1048 67 449 1110
Metabolic health status
 Metabolically healthy 1254 1163 109 662 1177
 Metabolically unhealthy 579 814 58 397 1284
BMI*Metabolic Health Z score mean (SD) 2.96 (30.38) 2.92 (31.59) 2.84 (30.4) 2.55 (29.0) 2.82 (31.4)
BMI mean (SD) 29.5 (5.9) 29.8 (6.1) 29.3 (6.9) 26.2 (4.3) 30.1 (6.2)
BMI categories
 Underweight 7 13 0 20 18
 Normal 417 420 41 435 444
 Overweight 641 680 67 429 912
 Obese 768 864 59 175 1087
Waist circumference mean (SD) 89.5 (13.8) 90.7 (13.7) 89.1 (15.1) 94.5 (12.8) 101.4 (15.1)
Triglycerides mean (SD) 153 (88.2) 146.9 (83.4) 143.8 (82.5) 140.4 (83.6) 117.3 (77.7)
HDL-cholesterol mean (SD) 58 (15.1) 52.1 (13.2) 53.2 (13.0) 52.3 (18.2) 53.3 (17.3)
Systolic blood pressure mean (SD) 128 (18) 132.1 (17.8) 132.5 (16.6) 118.7 (18.0) 127.3 (20.6)
Diastolic Blood Pressure mean (SD) 75.3 (9.4) 76.4 (9.3) 76.3 (8.5) 68.5 (9.7) 75.2 (10.7)
Blood glucose mean (SD) 103 (31.1) 108.6 (41.3) 105.2 (37.2) 105.9 (28.6) 129.3 (64.3)
  1. Means [standard deviation (SD)] or proportions have been included
  2. EMPC, epigenetic mechanisms of particulate matter-mediated cardiovascular disease; BAA23, the integrative genomics for risk of coronary heart disease and related phenotypes in WHI cohort; AS311, bladder cancer and leukocyte methylation; BMI, Body Mass Index; EA, European American; AA, African American