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Table 1 Demographic characteristics of each ancillary study in the Women’s Health Initiative (WHI) and the Atherosclerosis Risk in Communities (ARIC)

From: Associations between DNA methylation and BMI vary by metabolic health status: a potential link to disparate cardiovascular outcomes

 

EMPC (n = 1833)

BAA23 (n = 1977)

AS311 (n = 167)

ARIC EA (n = 1059)

ARIC AA (n = 2461)

Clinical trial participant

 Yes

1833

1543

119

–

–

 No

0

434

48

–

–

Case/control status

 Case

–

987

91

–

–

 Control

–

990

76

–

–

Age mean (SD)

63.2 (7.1)

64.6 (7.1)

66.2 (7.2)

59.9 (5.4)

56.6 (5.9)

Sex

 Female

1833

1977

167

611

1574

 Male

0

0

0

448

887

Ethnicity

 White

922

944

99

1059

0

 African American

474

631

49

0

2461

 Hispanic/Latino

260

402

16

0

0

 Asian or Pacific Islander

107

0

2

0

0

 American Indian or Alaskan Native

41

0

1

0

0

 Other

29

0

0

0

0

Smoking status

 Former and current

853

913

99

610

1351

 Never

963

1048

67

449

1110

Metabolic health status

 Metabolically healthy

1254

1163

109

662

1177

 Metabolically unhealthy

579

814

58

397

1284

BMI*Metabolic Health Z score mean (SD)

2.96 (30.38)

2.92 (31.59)

2.84 (30.4)

2.55 (29.0)

2.82 (31.4)

BMI mean (SD)

29.5 (5.9)

29.8 (6.1)

29.3 (6.9)

26.2 (4.3)

30.1 (6.2)

BMI categories

 Underweight

7

13

0

20

18

 Normal

417

420

41

435

444

 Overweight

641

680

67

429

912

 Obese

768

864

59

175

1087

Waist circumference mean (SD)

89.5 (13.8)

90.7 (13.7)

89.1 (15.1)

94.5 (12.8)

101.4 (15.1)

Triglycerides mean (SD)

153 (88.2)

146.9 (83.4)

143.8 (82.5)

140.4 (83.6)

117.3 (77.7)

HDL-cholesterol mean (SD)

58 (15.1)

52.1 (13.2)

53.2 (13.0)

52.3 (18.2)

53.3 (17.3)

Systolic blood pressure mean (SD)

128 (18)

132.1 (17.8)

132.5 (16.6)

118.7 (18.0)

127.3 (20.6)

Diastolic Blood Pressure mean (SD)

75.3 (9.4)

76.4 (9.3)

76.3 (8.5)

68.5 (9.7)

75.2 (10.7)

Blood glucose mean (SD)

103 (31.1)

108.6 (41.3)

105.2 (37.2)

105.9 (28.6)

129.3 (64.3)

  1. Means [standard deviation (SD)] or proportions have been included
  2. EMPC, epigenetic mechanisms of particulate matter-mediated cardiovascular disease; BAA23, the integrative genomics for risk of coronary heart disease and related phenotypes in WHI cohort; AS311, bladder cancer and leukocyte methylation; BMI, Body Mass Index; EA, European American; AA, African American