Box 1 DNAm classification score generation using Maas et al. stepwise regression data

For each individual in our DNAm data, a weighted score was obtained by multiplying the normalised methylation value at a given CpG by the effect size Maas et al. then summing these values:

b₁cpg₁ + b₂cpg₂ + … + b₁₃cpg₁₃

where “cpg” is the normalised methylation value in our dataset and “b” is the effect size from Maas et al. Additional file 4: Table S3