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Table 1 Overview H3K36me3-associated regulators in different cancers

From: H3K36 trimethylation-mediated biological functions in cancer

Cancer subtype Signaling pathway Category Mechanism Function Role
Colorectal cancer Wnt/β-catenin signaling pathway KDM4C: overexpression Upregulating MALAT1 expression Metastasis Promoter
   SETD2: mutation Aberrant Dvl2 alternative splicing Tumorigenesis Suppressor
Liver cancer AP-1 pathway SETD2: mutation Dysregulated cholesterol homeostasis Tumorigenesis Suppressor
    P53 inhibition   
Pancreatic cancer / SETD2: mutation Promoting acinar-to-ductal transition Transformation Suppressor
     Progression  
Lung cancer CXCL1-associated signaling pathway SETD2: mutation Aberrant FGFR-2 gene alternative splicing Tumorigenesis Promoter
    CXCL1-mediated activation of cell cycle Proliferation Suppressor
    P53 inactivation metastasis  
    Dysregulation of gene expression Prognosis  
Breast cancer / SETD2: mutation Unstrained expression of oncogenes Metastasis Suppressor
   H3 mutation   Prognosis  
Renal cancer Wnt/β-catenin signaling pathway SETD2: mutation; loss Genome reprogramming Tumorigenesis Suppressor
    Defective DNA methylation Prognosis  
    Defective DSBs repair   
    P53 inhibition   
Pediatric cancer / H3F3A/H3F3B: mutation Histone methylation reprogramming Transformation Suppressor
   SETD2: mutation; loss Upregulation of oncogenes Tumorigenesis Promoter?
    Impair MMR   
Prostate cancer AMPK signaling pathway SETD2: mutation Altering histone methylation landscape Progression Suppressor
Hematological malignant tumor / SETD2: mutation Dysregulation and malignant transformation of hematopoietic stem cells Tumorigenesis Suppressor
  1. This table lists the role of H3K36me3-associated epigenetic regulators in different cancer types, including their genetic alternations, related cellular signaling pathways, and which stage of cancer processes their predominantly affect. Pediatric cancer refers to glioblastoma, chondroblastoma, giant cell tumors of bone. The symbol “/” means unknown