Fig.2
From: H3K36 trimethylation-mediated biological functions in cancer
H3K36me3 engages in essential cellular possesses. a Active and repressive histone marks maintain gene transcriptional homeostasis. b H3K36me3 regulates transcription-related events, including transcription elongation, pre-mRNA alternative splicing, and mRNA m6A modifications. Transcription elongation promotes gene transcription. c H3K36me3 affects DNA methylation of local DNA and CpG islands through the interaction with DNMTs. DNA methylation mediated by H3K36me3 represses aberrant transcription. d H3K36me3 facilitates MMR and DSBs repair to keep genomic stability