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Fig. 6 | Clinical Epigenetics

Fig. 6

From: Cell-free DNA 5-hydroxymethylcytosine profiles of long non-coding RNA genes enable early detection and progression monitoring of human cancers

Fig. 6

Development and internal validation of a classification model (5hmC-score) based on tissue-specific plasma-derived 5hmC-modified lncRNA genes. Heatmap showing the distribution of the 5hmC-score and 5hmC levels for different cancer types in the A training and C independent validation cohorts. ROC curve and AUC value of the 5hmC-score for identifying tumor origin and location in the B training and D independent validation cohorts. AUC, area under the ROC curve; CC, colon cancer; GC, gastric cancer; HCC, hepatocellular carcinoma; 5hLC-score, 5hmC-lncRNA classification score; TPM, transcripts per million

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Clinical Epigenetics

ISSN: 1868-7083

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