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Fig. 4 | Clinical Epigenetics

Fig. 4

From: Cell-free DNA 5-hydroxymethylcytosine profiles of long non-coding RNA genes enable early detection and progression monitoring of human cancers

Fig. 4

Further independent validation of the 5hLD-score. The 5hmC modification heatmap, boxplots and receiver operating characteristic curve of the 5hLD-score in the A validation-1 cohort comprising 1251 HCC and 570 healthy control samples, B validation-2 cohort comprising 150 EC and 183 healthy control samples and C validation-3 cohort comprising 66 NSCLC and 67 healthy control samples. Statistical significance was determined using the Wilcoxon rank-sum test. HCC, hepatocellular carcinoma; EC, esophageal cancer; NSCLC, non-small-cell lung cancer; AUC, area under the curve; 5hLD-score, 5hmC-LncRNA diagnostic score

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Clinical Epigenetics

ISSN: 1868-7083

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