Fig. 1

Analysis of ATAC-seq and RNA-seq datasets from GBM patient samples showed the overlapping increased chromatin accessibility within a region and possible pathways involved in GBM tumorigenesis. a Flow chart of analysis of ATAC-seq and RNA-seq datasets from GBM patient samples. b Analysis of differential chromatin accessibility within the regions showed the significantly increased accessibility within the regions from two different sets of tumor samples (tumor vs. normal and short-survival vs. long-survival). c Venn diagrams of overlapping subsets showed the number of overlapping significantly increased accessibility within the regions between these two different sets of tumor samples (tumor vs. normal and short-survival vs. long-survival). d Pie plot showed the categorization of genomic regions through annotation of consistently increased accessibility within the regions. N = 143 represented the regions that were located in the promoter. e KEGG gene ontology analysis of increased accessibility within the regions showed the pathways that may be involved in GBM tumorigenesis