Fig. 3

Consensus clustering for DNA methylation of HGSOC. A Consensus cumulative distribution function (CDF) plot. The CDF plot shows the cumulative distribution functions of the consensus matrix for each k (indicated by colours). B Delta area plot. This graph shows the relative change in area under the CDF curve. In k = 4, the shape of the curve approaches the ideal step function, and the shape hardly changes as we increase K past 4. Therefore, four clusters were chosen as the optimal number. C Heat map generated using the pheatmap function with DNA methylation classification. The left bar represents the significantly different DNA methylation loci (Table 2)