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Table 1 Table summarizing the proportion of estrogen (ER) and progesterone receptor (PR) positive tumor cells, the results from HER2 immunohistochemistry (IHC) and silver in situ hybridization (SISH), the Ki67 proliferation rate as well as histopathological grading of LowHR samples included in this study

From: DNA methylation profiling identifies two distinct subgroups in breast cancers with low hormone receptor expression, mainly associated with HER2 amplification status

Case #

ER (%)

PR (%)

HER2 IHC

HER2 SISH

Ki67 (%)

Grading

cT

cN

1

8

0

1+

Not done

80

G3

cT2

cN−

2

5

0

3+

Not done

30

G3

cT2

cN+

3

2

0

3+

Positive

15

G2

cT2

cN+

4

5

0

2+

Positive

40

G3

cT2

cN+

5

5

0

3+

Positive

15

G2

cT2

cN−

6

5

0

3+

Positive

40

G3

cT2

cN−

7

5

0

3+

Not done

30

G3

cT2

cN+

8

0

3

1+

Not done

90

G3

cT1

cN−

9

5

0

2+

Negative

70

G3

cT2

cN−

10

0

5

3+

Not done

70

G3

cT2

cN−

11

3

0

0

Not done

80

G3

cT3

cN+

12

5

0

0

Not done

80

G3

cT1

cN+

13

 < 1

8

3+

Not done

20

G3

cT4

cN+

14

5

0

0

Not done

50

G3

cT1

cN+

15

8

8

3+

Not done

73

G3

cT2

cN+

16

2

0

2+

Negative

50

G3

cT2

cN−

17

3

2

2+

Negative

85

G3

cT1

cN−

18

3

 < 1

3+

Not done

40

G3

cT2

cN−

19

3

0

2+

Negative

30

G3

cT2

cN−

20

0

5

0

Not done

95

G3

cT2

cN−

21

2

0

2+

Positive

90

G3

cT2

cN−

22

0

5

3+

Not done

38

G3

cT2

cN−

23

2

0

3+

Not done

35

G3

cT2

cN+